William Erb

UR1 Associate professor

Email : william [dot] erb [at] univ-rennes1 [dot] fr

Phone : +33 (0) 2 23 23 58 45

Office number : Beaulieu 10A, Office 007/2

Research themes

Scientific skills

  • Synthesis of polysubstituted ferrocene derivatives
  • Aromatic heterocycles
  • Copper and palladium catalysis
  • Substituent effects

Education and professional experience

  • Habilitation (2020). Jury: Pr. Anne-Sophie Castanet, Dr. Gilles Gasser, Pr. Florence Mongin, Pr. Olivier Riant and Dr. Jean-François Soulé.
  • Associate professor (2015-) - Université de Rennes 1, Institut des Sciences Chimiques de Rennes, UMR 6226 (France).
  • Postdoctoral research associate (2014-2015) - COBRA (Rouen, France). Group of Pr. Géraldine Gouhier.
  • Postdoctoral research associate (2013-2014) - ENSICaen (Caen, France). Group of Pr. Jacques Rouden.
  • Assistant professor (2012-2013) - ESPCI ParisTech (Paris, France). Group of Pr. Janine Cossy.
  • Postdoctoral research associate (2011-2012) - University of Bristol (Bristol, England). Group of Pr. Varinder Aggarwal.
  • PhD (2007-2010) - Université de Paris-Sud XI - ICSN (Gif-sur-Yvette, France). Supervisor: Pr. Jieping Zhu.

Scientific production

Since he took up his present position, he's scientific interest goes to the asymmetric synthesis of ferrocene derivatives, especially polysubstituted ones. His interests also include the functionalization of aromatic compounds such as heterocycles to reach biologically active molecules.

Selected publications
1. Functionalization of 3-Iodo-N,N-diisopropylferrocenecarboxamide, a Pivotal Substrate to Open the Chemical Space to 1,3-Disubstituted Ferrocenes.
Erb, W.; Kadari, L.; Al-Mekhlafi, K.; Roisnel, T.; Dorcet, V.; Radha Krishna, P.; Mongin, F. Adv. Synth. Catal. 2020, DOI : 10.1002/adsc.201901393. VIP paper.
2. Functionalization of 9-thioxanthone at the 1-position: from arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest.
Mokhtari Brikci-Nigassa, N. ; Nauton, L.; Moreau, P.; Mongin, O.; Duval, R.; Picot, L.; Thiéry, V.; Souab, M.; Ruchaud, S.; Bach, S.; Le Guevel, R.; Bentabed-Ababsa, G.; Erb, W.; Roisnel, T.; Dorcet, V.; Mongin, F. Bioorg. Chem. 2019, 94, 103347.
3. From ferrocene to fluorine-containing penta-substituted derivatives and all points in-between; or, how to increase the available chemical space.
Tazi, M.; Erb, W.; Roisnel, T.; Dorcet, V.; Mongin, F.; Low, P. J. Org. Biomol. Chem. 2019, 17, 9352-9359.
4. Enantioselective deprotometalation of N,N-dialkyl ferrocenecarboxamides using metal amides.
Hedidi, M.; Dayaker, G.; Kitazawa, Y.; Tatsuya, Y.; Kimura, M.; Erb, W.; Bentabed-Ababsa, G.; Chevallier, F.; Uchiyama, M.; Gros, P. C.; Mongin F. New J. Chem. 2019, 43, 14898-14907.
5. Asymmetric synthesis of hetero-1,2,3,4,5-pentasubstituted ferrocenes.
Erb, W.; Roisnel, T. Chem. Commun. 2019, 55, 9132-9135.
6. Ferroceneboronic acid and derivatives: synthesis, structure, electronic properties and reactivity in directed C-H bond activation.
Erb, W.; Hurvois, J.-P.; Roisnel, T.; Dorcet, V. Organometallics 2018, 37, 3780-3790.
7. Fluoro- and Chloroferrocene: From 2- to 3‑Substituted Derivatives.
Tazi, M.; Hedidi, M.; Erb, W.; Halauko, Y. S.; Ivashkevich, O. A.; Matulis, V. E.; Roisnel, T.; Dorcet, V.; Bentabed-Ababsa, G.; Mongin, F. Organometallics 2018, 37, 2207-2211.
8. From 2- to 3‑Substituted Ferrocene Carboxamides or How to Apply Halogen ‘Dance’ to the Ferrocene Series.
Tazi, M.; Erb, W.; Halauko, Y. S.; Ivashkevich, O. A.; Matulis, V. E.; Roisnel, T.; Dorcet, V.; Mongin, F. Organometallics 2017, 36, 4770-4778.
9. Fused Systems Based on 2-Aminopyrimidines: Synthesis Combining Deprotolithiation-in situ Zincation with N-Arylation Reactions and Biological Properties.
Hedidi, M.; Maillard, J.; Erb, W.; Lassagne, F.; Halauko, Y. S.; Ivashkevich, O. A.; Matulis, V. E.; Roisnel, T.; Dorcet, V.; Hamze, M.; Fajloun, Z.; Baratte, B.; Ruchaud, S.; Bach, S.; Bentabed-Ababsa, G.; Mongin, F. Eur. J. Org. Chem. 2017, 5903-5915.


Publications referenced in HAL