Biosourced surfactants and glycolipids
One of the specialties of Corint is the synthesis of environmentally-friendly surfactants from renewable materials through green chemistry processes. In particular, we developed original, 100% biosourced anionic and cationic polyglycosylated surfactants. These surfactants, which are based either on uronic acid from algae or pectins (for anionic surfactants), or derived from beet betaine glycine (for cationic surfactants), meet an industrial need and are marketed through a spin-off of CoRInt: SurfactGreen. They are characterized for their surface-active properties by tensiometry, their rheological models as well as their structural properties.
The biological recognition properties of glycosylated lipids are also exploited to develop innovative therapeutic formulations. For example, a messenger/polymer RNA complex encapsulated in a trimannosylated lipid targets the dendritic cells of the spleen and activates the anti-tumor immune defense, showing a better efficacy than immunotherapy.
Engineering of polymer–nanoparticle hybrid nanocapsules: hybridosomes
We developed a new process to produce hybrid nanocapsules, hybridosomes®, based on an unconventional emulsification, the Ouzo effect. This process allows, in a single step, the formation of a shell of nanoparticles and the encapsulation of a hydrophobic active ingredient, each of which can have an imaging and therapeutic function. For example, hybridosomes containing nanoparticles (iron oxide and gold) and encapsulating a dye can be used simultaneously for MRI, fluorescence imaging and radiotherapy.
Nanoparticles made from biodegradable polymers enable the delivery of drugs or imaging agent. We develop poly(malic acid)-nanoparticles for the targeted delivery of radioelements, using via GBVA10-9 and CPB peptides for the diagnosis and/or therapy of hepatocellular carcinoma.
For more information : Sandrine Cammas-marion
Self-Assembly of water sensitive sugar-boronate gelators
We developed a new family of small organogelators based on a sugar platform equipped with a boronate function. We demonstrated recently that such molecules are able to induce gelation of several organic solvents. One of the main innovative property of this family takes advantage of the water sensitivity of the boronate function leading to water sensitive soft materials.
Disassembly mechanisms of complexes containing nucleic acids for gene release
A new project looking up to study the disassembly mechanisms of particles containing nucleic acids (DNA, ODN, mRNA) and natural/synthetic polycations or cationic lipids, in physicochemical conditions found in the extracellular and intracellular environment, has just started. Natural or synthetic polycations and cationic lipids are used in nucleic acid therapeutics, such as new mRNA vaccines or gene therapy, as complexing agents that interact electrostatically with nucleic acids, condense them into nanoparticles, protect them and control their entry release into cells. In this project, we expect to identify and examine the possible stages of the disassembly mechanisms of different particles, which may provide the basis for future improvement of the efficacy of nonviral vectors for gene delivery.
For more information : Lourdes Monica Bravo Anaya