Solène Guiheneuf-Vacher


Picture of Solène Guiheneuf-Vacher

Email : solene [dot] guiheneuf [at] univ-rennes1 [dot] fr

Office number : Building 10A


In 2008 I performed an internship for Sanofi Aventis in Toulouse and in 2009 I got a Master 2 in Chemistry at Université de Nantes. Then I obtained my PhD in therapeutic chemistry from Université de Rennes 2012 under Pr JP Bazureau supervision (ISCR, COrInt). I developped other analogs in 2014-2015 for a collaborative project with ManRos Therapeutics company under Pr JP Bazureau supervision (ISCR, COrInt).

From 2012 to 2014 I worked in environmental chemistry on the hydrophobic VOC absorption in Ionic Liquids and biodegradation in TTPB reactor at Université de Rennes (ISCR, COrInt-CIP) under Dr L Paquin supervision.
In 2015 I integrated MaCSE to develop electrolytes for redox flow batteries at Université de Rennes and Kemiwatt company.


  1. Polyaminoquinoline Iron Chelators for Vectorization ofAntiproliferative Agents: Design, Synthesis and Validation. V.Corcé, et al. Bioconjugate Chemistry 2012, 23(9), 1952. IF 4.818
  2. An efficient approach to Dispacamide A and derivatives. S.Guihéneuf, et al. Organic & Biomolecular Chemistry 2012, 10, 978. IF 3.564
  3. New 5-ylidene rhodanine derivatives based on the Dispacamide A model. S.Guihéneuf, et al. Molecular Diversity, 2014, 18(2), 375. IF 1.752
  4. Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A derivatives bearing a thiazolinone platform, biological assays on inhibition of proteine kinases and cell effects. S.Guihéneufet al. Current Microwave Chemistry 2014, 1(1), 33. IF 1.25
  5. Synthesis and toxicity evaluation of hydrophobic Ionic Liquids for Volatile Organic Compounds biodegradation in a two-phase partitioning bioreactor. A.S.Rodriguez et al. Journal of Hazardous Materials 2016, 307, 221. IF 6.065
  6. Toluene degradation in a two-phase partitioning bioreactor involving a hydrophobic Ionic Liquid as a non-aqueous phase liquid. A.S.Rodriguez Castillo, et al. International Biodeterioration & Biodegradation 2017, 117, 31. IF 2.962
  7. Evolution of DMSP (dimethylsulfoniopropionate) biosynthesis pathway: Origin and phylogenetic distribution in polyploid Spartina (Poaceae, Chloridoideae). H. Rousseau et al. Molecular phylogenetics and Evolution 2017, 114, 401. IF 4.419
  8. Marine derived 2-aminoimidazolone alkaloids. Leucettamine B -related polyandrocarpamines inhibit mammalian and protozoan DYRK &/CLK kinases. N.Loaëc et al. Marine Drugs 2017, 15, 316. IF 3.5
  9. Physicochemical properties of some hydrophobic room-temperature ionic liquids applied to volatile organic compounds biodegradation processes. A.S.Rodriguez et al. Journal of Chemical Technology and Biotechnology 2018, 93, 1, 215. IF 3.135
  10. Impact of activated sludge acclimation on the biodegradation of toluene absorbed in a hydrophobic Ionic Liquid. A.S.Rodriguez et al. International Journal of Environmental Science and Technology 2018, 15, 621. IF 1.915
  11. Assessment of VOC absorption in hydrophobic ionic liquids: measurement of partition and diffusion coefficients and simulation of a packed column. A.S.Rodriguez et al. Chemical Engineering Journal 2018, accepted for publication. IF 6.735


  1. Use of ionic liquids for the treatment of volatile organic compounds. WO 2016001609, 2016. S.Guihéneuf, et al.
  2. Use of Ionic Liquids as additives for electrochemistry. WO 2017212179, 2017. Floner D. et al. Chapitres de livres
  3. Microwaves in Heterocyclic Chemistry, Chapitre 14, in : Microwaves in Organic Chemistry, A.Loupy, A. de La Hoz, Eds., Third Edition, Wiley-VCH : Weinheim, Germany, 2012 J.P.Bazureau*, et al.
  4. Potential of liquid ionic for hydrophobic organic pollutants absorption and biodegradation in multiphase systems, Chapitre 11, in Other aspects related to biomass - ionic liquid system, Springer, 2013. S.Guihéneuf, et al.

Other Publications

Zoom sur … Le Développement de nouveaux inhibiteurs de kinases dérivés de l’alcaloïde marin, le Dispacamide A, contre le cancer – Équipe du Pr Jean Pierre Bazureau et du Dr François Carreaux à l’ISCR de Rennes 1, Lettre d’information - Axe Valorisation des produits de la mer en cancérologie Janvier-Février-Mars-Avril 2013.