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Home > Members > Permanents > Christophe Darcel

Prof. Christophe Darcel

Full professor in organometallic chemistry and catalysis

Institut des Sciences Chimiques de Rennes
UMR 6226 CNRS - Université Rennes 1
Campus de Beaulieu - Building 10C - Room 040
35042 Rennes Cedex - France

Phone : 33 (0) 2 23 23 62 71
Email: christophe.darcel@univ-rennes1.fr

Education and professional experience

  • Christophe Darcel studied chemistry at the University of Rennes 1, where he got his Ph.D. in 1995 under the supervision of C. Bruneau and P.H. Dixneuf on ruthenium and palladium catalysed transformations of functional alkynes.
  • He first spent one year as a postdoctoral fellow in Geneva with W. Oppolzer on sultam chemistry applied to the synthesis of natural products.
  • He then obtained a Humboldt fellowship and joined P. Knochel’s group in Marburg working on chiral zinc chemistry.
  • He was then appointed at the University of Cergy-Pontoise, and at the University of Burgundy as an associate professor. During this period, he developed methodology on P-chirogenic ligands for asymmetric catalysis.
  • In 2007, he was appointed a full professor at the University of Rennes 1.

Teaching

  • Homogeneous catalysis (Cross coupling reactions, carbonylation, C-H activation), 2nd year of international Master “Catalysis, Molecules and Green chemistry” (in English)
  • Homogeneous catalysis (Cross coupling reactions, carbonylation, C-H activation), 2nd year of Master Molecular Chemistry (in French)
  • Molecular synthesis and retrosynthesis, 2nd year of international Master “Catalysis, Molecules and Green chemistry” (in English)
  • Organometallic Chemistry and Synthesis, 2nd year of international Master “Catalysis, Molecules and Green chemistry” (in English)
  • Organometallic Synthesis, 1st year of Master of Chemistry (in French)
  • Organometallic Chemistry, 3rd Year of Licence of chemistry (in French)
  • Organic chemistry 3rd Year of Licence of biochemistry (in French)
  • “Agrégation” of physics (Chemistry lessons)

Collective Investment

  • Head of the international Master « Molecular Catalysis and Green Chemistry »since 2012 Vice-head of the team «Organometallics, Materials and Catalysis » part of the CNRS unit UMR CNRS “Institut des Sciences Chimiques de Rennes” (since 2016).
  • Member of the executive board of the CNRS Federation “INCREASE” since 2016
  • Head of the CNRS LIA ChemSusCat Rennes-Rostock since 2017 Member of the CNRS evaluation and recruitment committee in organometallic chemistry and catalysis (2012-2016)
  • Member of the chemistry department council (section chimie) and of the faculty “Science de la Matière” council.
  • Chairman of conferences - SAJEC 2004 (National); 2nd and 3rd Green International Green Catalysis Symposium - Advanced Spring School on Green Catalysis (2014 and 2017)
  • Vice-chairman of conferences - Green International Green Catalysis Symposium - Advanced Spring School on Green Catalysis 2012 (International)
  • Member of organizing committees - ICOMC 2008 (International); International Symposium on Chemistry of Concerto Catalysis Based on Synergy of Elements (international), Journées André Collet de la Chiralité 2009 (national), ISOM 2011 (international); Journées André Collet de la Chiralité 2012 (National); 2nd International Symposium on C-H bond activation 2014 (International)
  • Chairman of the session of « Organometallic Catalysis » of ICCC 2016 (International) and of the session catalytic system of the 3rd International Green Chemistry Symposium 2017

Research interests and selected recent publications

Our goal: use of organometallic catalysis to design greener approaches to organic synthesis for fine chemistry.

Our research interests focus on the fields of Organometallic Homogeneous Catalysis and its application towards the green chemistry and fine chemistry. The central theme of our research is the design of new earth abundant complexes (based on iron, but also manganese, nickel, etc.) with peculiar architectures, and their applications in homogeneous catalyzed processes relevant to fine chemical synthesis.

Our current efforts are in particular focused on the use of organometallic catalysts, especially those based on Iron and Nickel.

  • (i) Iron Cataysts and green chemistry;
  • (ii) C-H activation and C-X and C-C bond formation
  • (iii) reduction catalyzed processes and application to bio-ressource transformation.
  • (iv) use of cheap and earth abundant transition metal in catalysis (manganese, cobalt, nickel)

Iron reduction and hydroelementation area

  • Direct synthesis of dicarbonyl PCP-iron hydride complexes and catalytic dehydrogenative borylation of styrene.
    S. Jiang, S. Quintero-Duque, T. Roisnel, V. Dorcet, M. Grellier, S. Sabo-Etienne, C. Darcel, J.-B. Sortais
    Dalton Trans. (2016) 45, 11101-11108.
  • Iron-catalyzed α-Alkylation of Ketones with Alcohols
    S. Elangovan, J.-B. Sortais, M. Beller and C. Darcel
    Angew. Chem. Int. Ed. (2015) 54, 14483–14486.
  • Knölker’s Iron Complexes Bearing a N-heterocyclic Carbene Ligand: Synthesis, Characterization, and Catalytic Dehydration of Primary Amides
    S. Elangovan, S. Quintero-Duque, V. Dorcet, T. Roisnel, L. Norel, C. Darcel, J.-B. Sortais
    Organometallics (2015) 34, 4521.
  • Iron catalyzed α-alkylation of ketones with alcohols
    S. Elangovan, J.-B. Sortais, M. Beller, C. Darcel
    Angew. Chem. Int. Ed. (2015) 54, 14483.
  • Iron Catalyzed C-H Borylation of Arenes
    T. Dombray, C. G. Werncke, S. Jiang, M. Grellier, L. Vendier, S. Bontemps, J.-B. Sortais, S. Sabo-Etienne, C. Darcel
    J. Am. Chem. Soc. (2015) 137, 4062.
  • Methylation of Secondary Amines Catalysed by N-Heterocyclic Carbene Piano-Stool Iron Complexes,
    J. Zheng, C. Darcel, J.-B. Sortais
    Chem. Commun. (2014) 50, 14229.
  • Iron-catalysed tandem isomerisation/hydrosilylation reaction of allylic alcohols with amines
    H. Li, M. Achard, C. Bruneau, J.-B. Sortais, C. Darcel
    RSC Advances (2014) 4, 25892-25897.
  • (NHC)Fe(CO)4 efficient pre-catalyst for selective hydroboration of alkenes.
    J. Zheng, J.-B. Sortais, C. Darcel
    ChemCatChem (2014) 6, 763-766.
  • Selective Reduction of Esters to Aldehydes under the Catalysis of Well-Defined NHC-Fe Complexes
    H. Li, L.C. Misal Castro, J. Zheng, T. Roisnel, V. Dorcet, J.-B. Sortais, C. Darcel
    Angew. Chem. Int. Ed. (2013) 52, 8045.
  • (Cyclopentadienyl)iron(II) Complexes of N-Heterocyclic Carbenes Bearing a Malonate or Imidate Backbone: Synthesis, Structure, and Catalytic Potential in Hydrosilylation
    V. César, L. C. Misal Castro, T. Dombray, J.-B. Sortais, C. Darcel, S. Labat, K. Miqueu, J.-M. Sotiropoulos, R. Brousses, N. Lugan, G. Lavigne
    Organometallics (2013) 32, 4643-4655.
  • Iron catalyzed hydrosilylation of esters
    D. Bézier, G. T. Venkanna, L. C. Misal Castro, J. Zheng, T. Roisnel, J.-B. Sortais, C. Darcel
    Adv. Synth. Catal. (2012) 354, 1879-1884.
  • Phosphine-Pyridine Iron Complexes: Synthesis, Characterizations and Application in Reductive Amination via Hydrosilylation Reaction
    H. Jaafar, H. Li, L. C. Misal Castro, J. Zheng, T. Roisnel, V. Dorcet, J.-B. Sortais, C. Darcel
    Eur. J. Inorg. Chem. (2012) 3546-3550.
  • Selective switchable iron-catalyzed hydrosilylation of carboxylic acids
    L. C. Misal Castro, H. Li, J.-B. Sortais, C. Darcel
    Chem. Commun. (2012) 48, 10514–10516.
  • Iron Piano-Stool Phosphine Complexes for Catalytic Hydrosilylation Reaction
    J. Zheng, L. C. Misal Castro, T. Roisnel, C. Darcel, J.-B. Sortais
    Inorg. Chim. Acta (2012) 380, 301-307.
  • Cyclopentadienyl-NHC Iron Complexes for Solvent Free Catalytic Hydrosilylation of Aldehydes and Ketones
    D. Bézier, F. Jiang, T. Roisnel, J.-B. Sortais, C. Darcel
    Eur. J. Inorg. Chem. (2012) 1333.
  • NHC-carbene Cyclopentadienyl Iron Based Catalyst for a General and Efficient Hydrosilylation of Imines
    L. C. Misal Castro, J.-B. Sortais, C. Darcel
    Chem. Commun. (2012) 48, 151-153.
  • N-Heterocyclic Carbene Piano-Stool Iron Complexes as Efficient Catalysts for Hydrosilylation of Carbonyl Derivatives.
    F. Fiang, D. Bézier, J.-B. Sortais, C. Darcel
    Adv. Synth. Catal. (2011) 353, 239-244.
  • Well-Defined Iron Dihydride Complex for Efficient Catalytic Hydrosilation of Aldehydes and Ketones under Visible Light Activation
    L. C. Misal Castro, D. Bézier, J.-B. Sortais, C. Darcel
    Adv. Synth. Catal. (2011) 353, 1279-1284.
  • Well-defined Cyclopentadienyl NHC iron Complex as the Catalyst for Efficient Hydrosilylation of Amides to Amines and Nitriles
    D. Bézier, G. T. Venkanna, J.-B. Sortais, C. Darcel
    ChemCatChem (2011) 3, 1747-1750.

    Earth abundant and 1st row metal catalyzed reduction and hydrogen borrowing

  • A. Bruneau-Voisine, D. Wang, T. Roisnel, C. Darcel, Christophe; J.-B. Sortais
    J. Catal. (2017) doi: 10.1016/j.jcat.2017.01.004.
  • Hydrogenation of ketones with a manganese PN3P pincer pre-catalyst
    A. Bruneau-Voisine, D. Wang, T. Roisnel, C. Darcel, Christophe; J.-B. Sortais
    Catal. Commun. (2017) 92, 1-4.
  • Half-Sandwich Manganese Complexes Bearing Cp Tethered N-Heterocyclic Carbene Ligands: Synthesis and Mechanistic Insights into the Catalytic Ketone Hydrosilylation
    D. A. Valyaev, D. Wei, S. Elangovan, M. Cavailles, V. Dorcet, J.-B. Sortais, C. Darcel, N. Lugan
    Organometallics (2016) 35, 4090-4098.
  • Efficient and selective N-alkylation of amines with alcohols catalyzed by manganese pincer complexes,
    S. Elangovan, J. Neumann, J.-B. Sortais, K. Junge, C. Darcel, M. Beller
    Nat. Commun (2016) 7, 12641.
  • Hydrogenation of Carbonyl Derivatives with Well-Defined Rhenium Pre-Catalyst
    D. Wei, T. Roisnel, C. Darcel, E. Clot J.-B. Sortais
    ChemCatChem (2017) doi: 10.1002/cctc.201601141
  • Hydrosilylation of Aldehydes and Ketones Catalyzed by Half-Sandwich Mn(I) N-Heterocyclic Carbene Complexes
    J. Zheng, S. Elangovan, D. A. Valyaev, R. Brousses, V. César, J.-B. Sortais, C. Darcel, N. Lugan, G. Lavigne
    Adv. Synth. Catal. (2014) 356, 1093-1097.
  • Hydrosilylation of imines catalysed by NHC-Nickel catalysts
    L. P. Bheeter, M. Henrion, M. J. Chetcuti, C. Darcel, V. Ritleng, J.-B. Sortais
    Catal. Sci. Technol. (2013) 3, 3111-3116.
  • Cobalt carbonyl based catalyst for hydrosilylation of carboxamides
    T. Dombray, C. Helleu, C. Darcel, J.-B. Sortais
    Adv. Synth. Catal. (2013) 355, 3358-3362.
  • Selective reduction of carboxylic acids to aldehydes through manganese catalysed hydrosilylation
    J. Zheng, S. Chevance, C. Darcel, J.-B. Sortais
    Chem. Commun. (2013) 49, 10010-10012.
  • Hydrosilylation of aldehydes and ketones catalyzed by an N-Heterocyclic Carbene-nickel hydride complex under mild conditions
    P. Bheeter, M. Henrion, L. Brelot, C. Darcel, M. J. Chetcuti, J.-B. Sortais, V. Ritleng
    Adv. Synth. Catal. (2012) 354, 2619-2624.
  • Nickel-Catalysed Reductive Amination with Hydrosilanes
    J. Zheng, T. Roisnel, C. Darcel, J.-B. Sortais
    ChemCatChem (2013) 5, 2861-2864.
  • A convenient nickel-catalysed hydrosilylation of carbonyl derivatives
    J. Zheng, C. Darcel, J.-B. Sortais
    Catal. Sci. Technol. (2012) 3, 81-83.
  • A Convenient Nickel-Catalyzed Hydrosilylation of Carbonyl Derivatives using PMHS as the hydrosilane
    J. Zheng, C. Darcel, J.-B. Sortais
    Catal. Sci. Technol. (2013) 3, 81-84.

Ruthenium catalyzed C-H activation

  • Cycloruthenation of aryl imines and N-heteroaryl benzenes via C-H bond activation with Ru(II) and acetate partners
    B. Li, C. Darcel, T. Roisnel, P. H. Dixneuf
    J. Organomet. Chem. (2015) 793, 200.
  • Sp3C–H bond alkylation of ketones with alkenes via ruthenium(II) catalysed dehydrogenation of alcohols
    B. Li, C. Darcel, P. H. Dixneuf
    Chem. Commun. (2014) 50, 5970-5972.
  • Sequential ruthenium(II)-acetate catalyzed C-H bond diarylation in NMP or water and hydrosilylation of imines
    B. Li, C. B. Bheeter, C. Darcel, P. H. Dixneuf
    Top. Catal. (2014) 57, 833–842.
  • Ruthenium(II) -catalysed Functionalisation of C-H Bonds via a Six-membered Cyclometallate: Monoarylation of Aryl 2-pyridyl Ketones
    B. Li, C. Darcel, P. H. Dixneuf
    ChemCatChem (2014) 6, 127-130.
  • Cyclometallation of arylimines and nitrogen-containing heterocycles via room-temperature C–H bond activation with arene ruthenium(II) acetate complexes
    B. Li, T. Roisnel, C. Darcel, P. H. Dixneuf
    Dalton Trans. (2012) 41, 10934-10937.
  • Ruthenium(II) catalysed synthesis of unsaturated oxazolines via arene C–H bond alkenylation
    B. Li, K. Devaraj, C. Darcel, P. H. Dixneuf
    Green Chem. (2012) 14, 2706-2709.
  • Catalytic C-H bond Arylation of Aryl Imines and Oxazolines in Water with Ruthenium(II)-Acetate Catalyst
    B. Li, K. Devaraj, C. Darcel, P. H. Dixneuf
    Tetrahedron (2012) 68, 5179-5184.
  • Sequential Catalysis for the Production of Sterically Hindered Amines: Ru(II)-Catalyzed C-H Bond Activation and Hydrosilylation of Imines
    B. Li, C. B. Bheeter, C. Darcel, P. H. Dixneuf
    ACS Catal. (2011) 1, 1221-1224.
  • Amine Synthesis via Mild Catalytic Polymethylhydroxysiloxane Hydrosilylation of Imines with [RuCl2(p-cymene)]2 catalyst
    B. Li, J.-B. Sortais, C. Darcel, P. H. Dixneuf
    ChemSusChem (2012) 5, 396-399.

Reviews and book chapters

  • Amine synthesis via transition metal homogeneous catalysed hydrosilylation
    B. Li, J.B. Sortais, C. Darcel
    RSC Adv. (2016) 6, 57603–57625.
  • Iron-catalysed Cross Dehydrogenative Coupling (CDC) reactions; Editeur: C.-J. Li, RSC Publishing, “C-H to C-C bonds: Cross Dehydrogenative Coupling”
    C. Darcel, J.-B. Sortais, S. Quintero Duque, 2015, pp 67-92. ISBN: 978-1-84973-797-5.
  • When iron met phosphines: a happy marriage for reduction catalysis
    L. C. Misal Castro, H. Li, J. B. Sortais, C. Darcel
    Green Chem. (2015) 17, 2283-2303.
  • N-Heterocyclic Carbene Ligands and Iron: An Effective Association for Catalysis
    D. Bézier, J.-B. Sortais, C. Darcel
    Adv. Synth. Catal. (2013) 355, 19-33.
  • Chiral Cyclopentadienyl type ligands: a New Breakthrough for Asymmetric C-H Functionalization
    J.-B. Sortais, C. Darcel
    ChemCatChem (2013) 5, 1067-1068. (Invited highlight)

Main Collaborations

  • Prof. Matthias Beller, LIKAT Rostock (Germany) on earth abundant transition metal catalyzed reductions (LIA ChemSusCat)
  • Dr. Noël Lugan, Vincent César and Dmitry Valyaev, LCC Toulouse (France) on Mn-catalyzed catalytic transformation
  • Dr. Sylviane Sabo-Etienne, Dr. Mary Grellier and Dr. Sébastien Bontemps LCC Toulouse (France) on iron-catalyzed hydroelementation reactions
  • Dr. Vincent Ritleng and Prof. Michael Checuti, University of Strasbourg (France) on Nickel catalysis
  • Prof. Prasenjit Ghosh, ITT Bombay (India) on NHC-transition metal complexes for catalysis
  • Prof. Ismail Ozdemir, University of Inonu, Malatya (Turkey) on NHC-iron catalysis

Publications referenced in HAL since 2006