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Dr Sophie Guillaume

CNRS Research Director in Polymer Chemistry

Institut des Sciences Chimiques de Rennes
UMR 6226 CNRS - Université Rennes 1
Campus de Beaulieu - Building 10C - Room 919
35042 Rennes Cedex - France

Phone : 33 (0) 2 23 23 58 80

ORCID: 0000-0003-2917-8657
Researcher ID: B-6018-2017

Education and professional experience

Professional Positions

  • 2011 Research director - CNRS (National Center for Scientific Research) – University of Rennes 1 - UMR 6226 – Institute of Chemical Sciences of Rennes (ISCR), Rennes, France
  • 2006-11 Senior research associate - CNRS – University of Rennes 1 - UMR 6226 - Institute of Chemical Sciences of Rennes (ISCR), Rennes, France
  • 2000-06 Senior research associate - CNRS – University of Bordeaux 1 - UMR 5629 - Laboratory of Chemistry of Organic Polymers (LCPO), Bordeaux, France
  • 1994-00 Research associate - CNRS - URA 331 - Laboratory of Reactivity & Mechanisms in Inorganic Chemistry (LRMCI), CEA Saclay, France
  • 1993-94 Research assistant - CEA (Alternative Energies and Atomic Energy Commission) – Department of Molecular Chemical Sciences, Saclay, France


  • 2004 Habilitation in Chemical Sciences – Polymer Chemistry - University of Bordeaux 1, Bordeaux, France
  • 2000 Master in Polymer - University of Bordeaux 1, Bordeaux, France
  • 1992 Ph. D. in Inorganic-Organometallic Chemistry - Syracuse University, Syracuse, New-York, USA
  • 1989 M. Sc. In Inorganic Chemistry - Syracuse University, Syracuse, New-York, USA
  • 1987 Teaching-Assistant certificate - Syracuse University, Syracuse, New-York, USA
  • 1987 Master in Chemistry - University of Bordeaux 1, Bordeaux, France

Research interests

My research interests mainly focus on polymer chemistry toward industrial and biomedical applications:

  • Green & biobased chemistry: Original monomers and polymers derived from bio-renewable resources; (bio)degradable polymers issued from the biomass
  • Polymerization: New catalytic systems (metallic, organic, multicomponent); molecular and homogeneous catalysis for polymers; synthesis of (co)polymers (ROP, ROMP, chemical modification, microstructurally-controlled polymers, stereoselective polymerization), characterization of (co)polymers (NMR 1D & 2D, SEC, HPLC, flash chromatography, DSC, TGA, TEM, SEM, FTIR, UV, contact angle); polymerization mechanisms, experimental & theoretical approaches (DFT)
  • Macromolecular engineering: Functionalized and reactive (co)polymers; polyesters, polycarbonates, polypeptides, polyurethanes, non-isocyanate polyurethanes (NIPUs), polyolefins, silyl modified polymers (SMPs); Copolymers (linear, star shaped, block, tapered, random): synthesis (sequential/simultaneous copolymerization, chemical modification), self-assembly of amphiphilic copolymers, formulation of nanoparticles
  • Polymers for the living: Biocompatible & biodegradable polymers; therapeutic polymers & diagnostic polymers: drug-delivery systems, thermogelling polymers, conjugated polymers
  • Organometallic chemistry: Transition metal complexes, «Single-site» catalysts

Current collaborations

  • Dr. S. Fouquay, Dr F. Simon, Dr G. Michaud (Bostik - Arkema, France): Non-isocyanate polyurethanes (NIPUs) and Silyl modified polyolefines (SMPs)
  • Dr J.-M. Brusson; Dr M. Slawinski; Dr M. Helou (Total Petrochemicals Research, Feluy, Belgique; Total SA, France): Catalytic polymerization of bio-based monomers
  • Pr C. Chassenieux (Institut des Molécules et Matériaux du Mans, Le Mans, France): Structure-physico-chemical properties relationship of nanoparticles derived from poly(hydroxyalcanoate)s
  • Prof. X. J. Loh (Institute of Materials Research and Engineering, Singapore): Novel thermo-responsive poly(hydroxyalkanoate)s based copolymers for biomedical applications
  • Prof. P. Roesky (Karlsruhe Institut of Technology (KIT), Karlsruhe, Germany): Novel rare earth organometallic complexes applied to the ring-opening polymerization of polar monomers


Teaching lectures in Polymers for MSc students in Catalysis & Molecular Chemistry (International program; University of Rennes 1, France)

Main Administrative and Collective Activities

  • Member of the Advisory board of Polymer Chemistry (RSC), of the Editorial Board of the Journal of Applied Polymer Science (Wiley), Frontiers in Chemistry-Polymer (Frontiers Media)
  • Manager of the French Group of Polymers “GFP”, Large West Region of France (2011 - present)
  • Member of the Council of the UMR 6226 – Institute of Chemical Sciences of Rennes (ISCR) (2011-16)
  • Member of the UFR Committee “Structure et Propriétés de la Matière” - University of Rennes 1 (2009-11)
  • Member of scientific executive committee at the Centre De Biotechnologie en Bretagne- CapBiotek Bretagne (CBB) (2008- present)

Main Honors, Awards

  • Région Bretagne ACOMB research award, 2007
  • Rennes Métropole AIS research award, 2008
  • University of Rennes Emerging Scientific Challenges grant, 2012
  • CNRS outstanding scientific PES award, 2010–14; 2014–18

Selected Recent Publications

  • From Epoxide to Cyclodithiocarbonate Telechelic Polycyclooctene through Chain-Transfer Ring-Opening Metathesis Polymerization (ROMP): Precursors to Non-Isocyanate Polyurethanes (NIPUs)
    E. Vanbiervliet, S. Fouquay, G. Michaud, F. Simon, J.-F. Carpentier, S. M. Guillaume
    Macromolecules (2017) 50, 69−82 - DOI: 10.1021/acs.macromol.6b02137
  • α,ω-Bis(trialkoxysilyl) difunctionalized polycyclooctenes from ruthenium-catalyzed chain-transfer ring-opening metathesis polymerization
    X. Michel, S. Fouquay, G. Michaud, F. Simon, J.-M. Brusson, J.-F. Carpentier, S. M. Guillaume
    Polymer Chemistry (2016) 7, 4810-4823 - DOI:10.1039/c6py00849f
  • New linear and star-shape thermogelling poly([R]-3-hydroxybutyrate) copolymers for controlled drug delivery
    G. Barouti, S. S. Liow, Q. Dou, H. Ye, C. Orione, S. M. Guillaume, X. J. Loh
    Chemistry- A European Journal (2016) 22, 10501–10512; Hot paper - DOI: 10.1002/chem.201601404
  • Polyhydroxyalkanoate-based amphiphilic diblock copolymers as original biocompatible nanovectors
    G. Barouti, K. Jarnouen, S. Cammas-Marion, P. Loyer,* S. M. Guillaume*
    Polymer Chemistry (2015) 6, 5414–5429 - DOI: 10.1039/c5py00831j
  • Block and random copolymers of 1,2-cyclohexyl cyclocarbonate and L-lactide or trimethylene carbonate synthesized by ring-opening polymerization
    A. K. Diallo, W. Guerin, M. Slawinski, J.-M. Brusson, J.-F. Carpentier, S. M. Guillaume
    Macromolecules (2015) 48, 3247–3256 - DOI: 10.1021/acs.macromol.5b00548
  • α,ω-Diglycerolcarbonate telechelic polyesters and polyolefins as precursors to non-isocyanate polyhydroxyurethanes
    L. Annunziata, A. K. Diallo, S. Fouquay, G. Michaud, F. Simon, J.-F Carpentier, S. M. Guillaume
    Green Chemistry (2014) 16, 1947-1956; themed issue “Sustainable Polymers: reduced environmental impact, renewable raw materials and catalysis; on invitation - DOI: 10.1039/C3GC41821A
  • From syndiotactic homopolymers to chemically tunable alternating copolymers: highly active yttrium complexes for stereoselective ROP of β-malolactonates
    C. G. Jaffredo, Y. Chapurina, S. M. Guillaume, J.-F. Carpentier
    Angew. Chem. Int. Ed. (2014) 53, 2687-2691 - DOI: 10.1002/anie.201310523

Publications referenced in HAL since 2006