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Dr Rafael Gramage-Doria

CNRS Researcher

Institut des Sciences Chimiques de Rennes
UMR CNRS 6226 - Université Rennes I
Campus de Beaulieu - Building 10C - Room 012
35042 Rennes Cedex

Phone : 33 (0) 2 23 23 58 00

Education and professional experience

Rafael Gramage-Doria received a double degree (BSc and Diplôme Ingénieur) from the University of Valencia and the Ecole de Chimie, Polymères et Matériaux of Strasbourg. In 2008 he obtained a MSc in Molecular and Supramolecular Chemistry from the University of Strasbourg conducting research under the supervision of Dr. F.R. Leroux in the laboratory of Prof. F. Colobert focusing on palladium catalysis. He did his PhD (2012) under the supervision of Prof. D. Armspach and Dr. D. Matt in the University of Strasbourg dealing with the synthesis, coordination properties and catalytic applications of molecular cavities. He joined the group of Prof. J.N.H. Reek at the University of Amsterdam as a NWO-Rubicon post-doctoral researcher investigating transition metal catalysis in confined spaces (2011-2014). After a short period (9 months) as post-doctoral researcher in the group of Prof. T. Ooi at Nagoya University, he took up a position at the CNRS as Chargé de Recherche (2015-present) in the Institut des Sciences Chimiques de Rennes (UMR 6226).

Research interests

  • Transition Metal Catalysis
  • Sustainability and Green Chemistry
  • C-H Bond Activation and Functionalization
  • New Chemical Disconnections
  • Oxidation and Hydrogenation Reactions
  • Tandem, Domino and Cascade Reactions
  • Mechanistic Studies
  • Step- and Atom-Economy Reactions
  • Supramolecular Chemistry and Catalysis
  • Noncovalent, Weak Interactions in Catalysis
  • Nature-Inspired Catalysis


  • Dr. Jean-Francois Halet and Dr. Samia Kahlal (Institut des Sciences Chimiques de Rennes, France): Theoretical calculations.
  • Vincent Dorcet and Dr. Thierry Roisnel (Institut des Sciences Chimiques de Rennes, France): X-ray diffraction studies.

Selected recent publications

  • “Ruthenium(II)-Catalyzed C-H (Hetero)Arylation of Alkenylic 1,n-Diazines (n = 2, 3, and 4): Scope, Mechanism, and Application in Tandem Hydrogenations”
    R. Gramage-Doria,* S. Achelle, C. Bruneau, F. Robin-le Guen, V. Dorcet, T. Roisnel
    J. Org. Chem. (2018) 83, 1462-1477.
  • “Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N‑Substituted Phthalimide Derivatives”
    Y.-C. Yuan, R. Kamaraj, C. Bruneau, T. Labasque, T. Roisnel, R. Gramage-Doria*
    Org. Lett. (2017) 19, 6404-6407.
  • “Palladium-Catalyzed Cross-Coupling Reactions Controlled by Noncovalent Zn...N Interactions”
    M. Kadri, J. Hou, V. Dorcet, T. Roisnel, L. Bechki, A. Miloudi, C. Bruneau, R. Gramage-Doria*
    Chem. Eur. J. (2017) 23, 5033-5043
  • “One-pot Directing Group Formation/C-H Bond Functionalization via Copper(I) and Ruthenium(II) Catalysis”
    C. Bruneau, R. Gramage-Doria*
    Adv. Synth. Catal. (2016) 358, 3847-3856
  • “Nonconventional Supramolecular Self-Assemblies of Zinc(II)-Salphen Building Blocks”
    T. Groizard, S. Kahlal, V. Dorcet, T. Roisnel, C. Bruneau, J.-F. Halet,* R. Gramage-Doria*
    Eur. J. Inorg. Chem. (2016) 5143-5151

Publications referenced in HAL since 2006