Marie-Laurence Abasq-Paofai

UR1 Associate Professor

Marie-Laurence Abasq-Paofai

Email : marie-laurence [dot] abasq [at] univ-rennes1 [dot] fr

Phone : +33 (0) 2 23 23 48 95

Office number : Villejean 05-East, Office 118

Summary

Marie Laurence Abasq received her PhD in Chemistry in 1994 at the University of Brest (France) under the supervision of Dr J. Talarmin, Pr. F.Y. Pétillon (UMR CNRS 6521) and of Pr C.J. Pickett, University of Sussex (G.B.), Unit of Nitrogen Fixation, where she completed a 6-month intership. After a postdoctoral position (Elf Atochem employment contract) in Pr. A. Shaver team at McGill University (Canada), she became lecturer in 1996 at the University of Rennes (France). She joined the ISCR (Institut des Sciences Chimiques de Rennes, CNRS 6226) in 2010. She possesses skills in the field of electrochemistry and her current research interests focus on studying the physicochemical properties of natural bioactive molecules.

Main Research themes

Polyphenols, dietary compounds, have drawn increasing attention due to their ability to lower oxidative stress involved in many pathologies and on their positive effects in modulation of redox cellular signalling pathways. The objectives of my current studies are to identify the compounds derived from polyphenols after cellular metabolization (neuronal cells and gut bacteria) and to highlight how these molecules can act beneficially on microbiota or to prevent neurodegeneresence diseases. A particular attention is paid on oxidized phenolic metabolites and their biological effects.

One of our projects focused on phenolic compounds from olive oil (oleuropein, tyrosol and p-coumaric acid) highly consumed in the Mediterranean diet. We have highlighted after treatment of SK-N-SH cells that combination of these compounds at low concentrations can counteract oxidative stress inducing neuronal death. A current project is carried on the gut-derived metabolites from dietary polyphenols. We focus our work in the bioconversion of 5-caffeoylquinic acid by intestinal bacterial species in mono and co-cultures. We have used Liquid Chromatography–Mass Spectrometry (LC-ESI-MS/MS) to identify metabolites after neuronal cells treatment and gut bacteria biotransformation. In addition, electrochemical technics were helpful to generate solution of oxidized phenolic compounds which were also evaluated and analyzed by LC-MS/MS for a better understanding of the redox mechanisms involved.

Education

PostDoctorat, McGill University, Canada, Department of Chemistry (Elf Atochem industrial contract) (1995-1996).

 

PhD, Chemistry, University of Brest URA CNRS 322 France, University of Sussex (Unit of Nitrogen Fixation) G.B., French government ministry grant, European Label (1991-1994)

International collaborations

Pr C.Ramassamy, INRS, Canada. Joint supervision of a PhD student (2014 – 2019)

Pr D. Nebija, Pristina, Kosovo. Co-supervision of a PhD student since 2018

Pr C. Lopez Alarcon, Santiago, Chili. Joint supervision of a master student in 2015

Administrative activities

Since 2008, international coordinator of the Faculty of Pharmacy, University of Rennes 1

Publications referenced in HAL