François-Hugues Porée

UR1 Professor

Organization:
Université de Rennes 1 - Faculté de Pharmacie
Address:

2 Avenue du Pr Léon Bernard

Locality:

Rennes 35000

France

Email : francois-hugues [dot] poree [at] univ-rennes1 [dot] fr

Phone : +33 (0) 2 23 23 41 87

Office number : Villejean 05, Office 034

Vitae


2019. Full Professor in Medicinal Chemistry (Institut des Sciences Chimiques de Rennes-UMR 6226, Université de Rennes 1 – Faculté de Pharmacie)

2012. HDR (habilitation). Université Paris Descartes

2005-2019. Assistant Professor (Laboratoire de Pharmacognosie UMR CNRS 8638, Faculté de Pharmacie de Paris - Université Paris Descartes)

2003-2004. Postdoctoral fellow at the Max Planck Institut für Kohlenforschung (Pr Fürstner)

2003. PhD in Organic Chemistry at Université de Cergy-Pontoise (Dr Pancrazi and Pr Ardisson) (Dina Surdin Award from the French Chemical Society)

2001. PhD in Pharmacy. Faculté de Pharmacie de Châtenay-Malabry, Université Paris Sud

2000. Master Degree in Organic Chemistry (Ecole Polytechnique, Palaiseau, France)

1976. Born in Paris (France)

Research Themes

  • Conception of libraries of natural product analogs for SAR studies
  • Total synthesis
  • Medicinal chemistry

keywords: alkaloids, synthesis, cancer 

Publications

Publications

P20. L. Shen, F.-H. Porée, T. Gaslonde, H. Lalucque, F. Chapeland-Leclerc, G. Ruprich-Robert. Functional characterization of the sterigmatocystin secondary metabolite gene cluster in the filamentous fungus Podospora anserina: involvement in oxidative stress response, sexual development, pigmentation and interspecific competitions Environmental Microbiology, 2019, DOI 10.1111/1462-2920.14698 (FI 5,147)

P19. E. Chirkin, C. Bouzidi, F.-H. Porée. Tungsten-Promoted Hetero-Pauson–Khand Cycloaddition: Application to the Total Synthesis of (–)-Allosecurinine. Synthesis 2019, 51, 2001-2006 (FI 2,650)

P18. P. Menelle, K. Cottet, Y. Fromentin, T. Gaslonde, F.-H. Porée, D. Buisson, M.-C. Lallemand. Progress on PPAPs cyclization: Guttiferone A as a case study. Tetrahedron Lett. 2017, 58, 4876-4879 (FI 2,193)

P17. F. Chapeland-Leclerc, A. Dilmaghani, L. Ez-Zaki, S. Boisnard, B. Da Silva, T. Gaslonde, F.-H. Porée, G. Ruprich-Robert. Systematic gene deletion and functional characterization of histidine kinase phosphorelay receptors (HKRs) in the human pathogenic fungus Aspergillus fumigatus. Fungal Genetics Biol., 2015, 84, 1-11 (FI 3,072)

P16. E. Chirkin, S. Michel, F.-H. Porée. Viability of a [2 + 2 + 1] Hetero-Pauson−Khand Cycloaddition Strategy toward Securinega Alkaloids: Synthesis of the BCD-Ring Core of Securinine and Related Alkaloids. J. Org. Chem. 2015, 80, 6525-6528 (FI 4,849)

P15. E. Chirkin, W. Atkatlian,Q. Do, T. Gaslonde, T.-H. Dufat, S. Michel, P. Lemoine, G. Genta-Jouve, F.-H. Porée. Chiroptical study and absolute configuration of securinine oxidation products. Nat. Prod. Res. 2015, 29, 1235-1242 (FI 1.828)

P14. M. Fomani, E. N. Happi, Kouam, F.-H Porée, M.-C. Lallemand, A. F. K. Waffo, J. D. Wansi. A prenylated acridone alkaloid and ferulate xanthone from barks of Citrus medica (Rutaceae). Z. Naturforsch. B, 2015, 70, 71-75

P13. X. Cachet, F.-H. Porée, S. Michel, P. Lemoine. Tetrahydroalstonine. Acta. Cryst. 2013, E69, o1389-1390

P12. L. Donati, P. Leproux, E. Prost, S. Michel, F. Tillequin, V. Gandon, F.-H. Porée. Solvent/Base Effects in the Selective Domino Synthesis of Phenanthridinones That Involves High-Valent Palladium Species: Experimental and Theoretical Studies. Chem. Eur. J. 2011, 17, 12809-12819 (FI 5,317)

P11. C. Genès, G. Lenglet, S. Depauw, R. Nhili, S. Prado, M.-H. David-Cordonnier, S. Michel, F. Tillequin, F.-H. Porée. Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c] phenanthrolinones as antiproliferative agents. Eur. J. Med. Chem. 2011, 46, 2117-2131 (FI 4,519)

P10. L. Donati, S. Michel, F. Tillequin, F.-H. Porée. Selective Unusual Pd-Mediated Biaryl Coupling Reactions: Solvent Effects with Carbonate Bases. Org. Lett. 2010, 12, 156-158 (FI 6,579)

P9. T. Serbetçi, C. Genès, S. Depauw, S. Prado, F.-H. Porée, M.-P. Hildebrand, M.-H. David-Cordonnier, S. Michel, F. Tillequin. Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents. Eur. J. Med. Chem. 2010, 45, 2547-2558 (FI 4,519)

P8. C. Genès, S. Michel, F. Tillequin, F.-H. Porée. Synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8] phenanthrolin-(5H)-6-ones through a Pd-mediated Suzuki–Miyaura heteroaryl-aryl coupling reaction. Tetrahedron 2009, 65, 10009-10015 (FI 2,651)

P7. Fürstner, L. C. Bouchez, L. Morency, J.-A. Funel, V. Liepnis, F.-H. Porée, R. Gilmour, D. Laurich, F. Beaufils, M. Tamiya. Total Syntheses of Amphidinolides B1, B4, G1, H1 and Structure Revision of Amphidinolide H2. Chem. Eur. J. 2009, 15, 3983-4010 (FI 5,317)

P6. E. de Lemos, F.-H. Porée, A. Bourin, J. Barbion, E. Agouridas, M.-I. Lannou, A. Commerçon, J.-F. Betzer, A. Pancrazi, J. Ardisson. Total Synthesis of Discodermolide: Optimization of the Effective Synthetic Route. Chem. Eur. J. 2008, 14, 11092-11112 (FI 5,317)

P5. E.de Lemos, F.-H. Porée, A. Commerçon, J.-F. Betzer, A. Pancrazi, J. Ardisson. a-Oxygenated Crotyltitanium and Dyotropic Rearrangement in the Total Synthesis of Discodermolide Angew. Chem. Int. Ed. 2007, 46, 1917-1921 (FI 11,994) (Synfacts 2007, 681)

P4. A. Fürstner, L. C. Bouchez, J.-A. Funel, V. Liepnis, F.-H. Porée, R. Gilmour, F. Beaufils, D. Laurich, M. Tamiya. Total Syntheses of Amphidinolide H and G. Angew. Chem. Int. Ed. 2007, 46, 9265-9270 (FI 11,994) (Synfacts 2008, 333)

P3. S. Centonze-Audureau, F.-H. Porée, J.-F. Betzer, J.-D. Brion, A. Pancrazi, J. Ardisson. Preparation of the three C1-C7, C8-C15 and C16-N22 fragments of the Hsp90 inhibitor Herbimycin A. Synlett 2005, 981-985 (FI 2,151)

P2. F.-H. Porée, J. Barbion, S. Dhulut, J.-F. Betzer, A. Pancrazi, J. Ardisson. Palladium-catalysed coupling reactions: (Z)-vinyl (N,N-diisopropyl)carbamate group as an efficient precursor of a (Z)-vinyl triflate function. Synthesis 2004, 3017-3022 (FI 2,650)

P1. F.-H. Porée, A. Clavel, J.-F. Betzer, A. Pancrazi, J. Ardisson. Efficient preparation of (Z)-alkenyl derivatives from (Z)-vinyl (N,N-diisopropyl)carbamate via Ni-catalysed coupling reactions. Tetrahedron Lett. 2003, 44, 7553-7556 (FI 2,193)


Reviews

_E. Chirkin, F.-H. Porée. The Diels-Alder reaction in total synthesis: a review of the state of the art during the period 2009-2014. Curr. Org. Chem. 2016, 20, 2284-2325. (FI 2,075)

_E. Chirkin, W. Atkatlian, F.-H. Porée, The Securinega Alkaloids. In The Alkaloids; Knölker, H.-J., Ed.; 2015; 74, pp 1–120

_D. Markovic, M. Kolympadi, B. Deguin, F.-H. Porée, M. Turks. The isolation and synthesis of neodolastane diterpenoids. Nat. Prod. Rep. 2015, 32, 230-255 (FI 11,014) Cover Picture

_X. Cachet, F.-H. Porée RSC Adv. 2013, 3, 12466-12484 (FI 3,108)

Publications referenced in HAL :