Enzyme‐like Supramolecular Catalysis Enabling Selective C−H Bond Functionalizations

An iridium catalyst featuring kinetically labile Zn⋅⋅⋅N interactions in the 2nd coordination sphere was found to display enzymatic behaviors
Enzyme‐like Supramolecular Catalysis Enabling Selective C−H Bond Functionalizations

An iridium‐based supramolecular catalyst has been designed to selectively recognize heterocycle derivatives via remote Zn⋅⋅⋅N interactions. Owing to the distance between the substrate binding site and the active site as well as the geometrically constraints, selective meta‐C-H bond borylations were accomplished with enzymatic Michaelis–Menten kinetics, besides unique substrate selectivity and dormant reactivity patterns.

A recent review dealing with this exciting topic has been published by the same colleagues.

The French National Research Agency (ANR-19-CE07-0039), H2020 Marie Skłodowska-Curie Actions (PCOFUND-GA-2013-609102) and Region Bretagne (SAD-2016 BIOCAT 9649, Boost'Europe BOSUPCAT 17004215) are acknowledged for financial support.

References

Contact

Rafael Gramage-Doria
Univ Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France
rafael [dot] gramage-doriaatuniv-rennes1 [dot] fr

 

Published May 4, 2021