An iridium‐based supramolecular catalyst has been designed to selectively recognize heterocycle derivatives via remote Zn⋅⋅⋅N interactions. Owing to the distance between the substrate binding site and the active site as well as the geometrically constraints, selective meta‐C-H bond borylations were accomplished with enzymatic Michaelis–Menten kinetics, besides unique substrate selectivity and dormant reactivity patterns.
A recent review dealing with this exciting topic has been published by the same colleagues.
The French National Research Agency (ANR-19-CE07-0039), H2020 Marie Skłodowska-Curie Actions (PCOFUND-GA-2013-609102) and Region Bretagne (SAD-2016 BIOCAT 9649, Boost'Europe BOSUPCAT 17004215) are acknowledged for financial support.
- "Enzyme‐Like Supramolecular Iridium Catalysis Enabling C‐H Bond Borylation of Pyridines with meta‐Selectivity”
J. Trouvé, P. Zardi, S. Al-Shehimy, T. Roisnel, R. Gramage-Doria*
Angew. Chem. Int. Ed. 2021, DOI: 10.1002/anie.202101997 (Hot Paper)
- “Beyond hydrogen bonding: recent trends of outer sphere interactions in transition metal catalysis”
J. Trouvé, R. Gramage-Doria*
Chem. Soc. Rev. 2021, 50, 3565-3584
Published May 4, 2021