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TOMASI Sophie– UR1 - Professor

Université de Rennes 1
Faculté des Sciences Pharmaceutiques et Biologiques
Pharmacie : Institut des sciences chimiques de Rennes - UMR 6226
2 - Av du Pr. Léon Bernard - CS 34317 - 35043 - RENNES CEDEX

Building 05-East, Desk 04- 41
Phone: +33 (0)

Research themes

• Study of lichen-associated bacteria communities and isolation of produced secondary metabolites (chemical ecology field)
• Isolation, structural identification of bioactive natural products
• Development of new extraction processes (microwave-assisted extraction, ionic liquids)
• Synthesis of natural products derivatives

Key words / Scientific skills

• Lichens and associated bacteria
• Natural products isolation and identification
• Chemical ecology
• Fermentation
• Drug discovery

Education and professional experience

• D. Sc. in Chemistry (1999), Université de Rennes 1
• Actual position (2011- ) Professor of Pharmacognosy, Fac. Pharmacy
• Post-doctoral fellow (02-05/2000) Canberra, Department of Chemistry, Dr R. Barrow, ANU
• PhD (1996/1999) Université de Rennes 1, Advisor: Pr P. Uriac
• Master Degree (1996) Université de Rennes 1, Advisor: Pr P. Uriac

Teaching activities

• Pharmacognosy
• Natural products chemistry
• Bioetchnology

Membership in professional organizations


Committee work

• GDR Mediatec.

Scientific Collaborations

• Pr M. Suzuki, LBBM, UPMC
• Pr M. Grube, University of Graz

Scientific Production

Parrot D., Antony-Babu S., Intertaglia L., Grube M., Tomasi S., Suzuki M.T. Littoral lichens as a novel source of potentially bioactive Actinobacteria. Sci Rep., 2015, 5, 15839, 1-15. DOI: 10.1038/srep15839

Millot M., Dieu A., Tomasi S. Dibenzofurans and derivatives from lichens and ascomycetes Nat. Prod Rep., 2016, 33(6), 801-811. DOI: 10.1039/c5np00134j

Komaty S., Letertre M., Dang H.D., Jungnickel H., Laux P., Luch A, Carrié D, Merdrignac-Conanec O., Bazureau J.P., Gauffre F., Tomasi S. , Paquin L. Sample preparation for an optimized extraction of localized metabolites in lichens : Application to Pseudevernia furfuracea Talanta 2016, 150, 525–530.

Parrot D., Legrave N., Intertaglia L., Rouaud I., Legembre P., Grube M., Suzuki M.T., Tomasi S. Cyaneodimycin, a bioactive compound isolated from the culture of Streptomyces cyaneofuscatus associated with Lichina confinis. European J. Org. Chem. 2016, 3977–3982. doi:10.1002/ejoc.201600252

Talapatra S.K., Rath O., Clayton E., Tomasi S., Kozielski F. Depsidones from lichens as natural product inhibitors of M‑Phase Phosphoprotein 1, a human kinesin required for cytokinesis. J. Nat. Prod. 2016, 79, 1576-1585. DOI: 10.1021/acs.jnatprod.5b00962

Publications referenced in HAL