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Sandrine CAMMAS-MARION

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Sandrine CAMMAS-MARION

CNRS Researcher (CR)

Institut des Sciences Chimiques de Rennes UMR 6226
ENSCR
11 Allée de Beaulieu
Campus de Beaulieu
35 708 Rennes, France
Building C, Desk 2.15
Phone: +33 (0) 2.23.23.81.09
Email: sandrine.marion.1@ensc-rennes.fr

Research themes

• Anionic or enzymatic (lipases) Ring Opening Polymerization (ROP) of β-substituted β-lactones in presence of functional initiators leading to well-defined amphiphilic block copolymers bearing functional groups at one end which can be chemically modified.
• Chemical modifications of (co)polymers to introduce molecules of interest such as targeting agents (biotin, peptides) and fluorescence probes.
• Design of biocompatible multifunctional nanoparticles by the self-assembling of amphiphilic block polyesters for applications as site-specific drug delivery systems;
• Study of the encapsulation of various biologically active molecules such as anti-cancer drugs, therapeutic genes and/or radio-elements and in vitro assays.
• Applications of such systems in the treatment of the hepatocellular carcinoma (HCC).

Key words / Scientific skills

• Synthesis and characterization of polymers and copolymers.
• Chemical modifications
• Formulation
• Characterization of nanoparticles
• In vitro assays

Education and professional experience

• Actual position (2005- ): Chargée de Recherche CNRS, ISCR – UMR 6226 CNRS, Equipe COS, Ecole Nationale Supérieure de Chimie de Rennes.
• Previous positions:

  • 2003-2005 : Chargée de Recherche CNRS, Laboratoire Organométalliques et Catalyse : Chimie et Electrochimie Moléculaire - UMR 6509 CNRS, Université de Rennes 1.
  • 2000-2003 : Chargée de Recherche CNRS, Laboratoire de Pharmacie Galénique - UMR 8612 CNRS, Université Paris Sud (Paris XI).
  • 1995-2000 : Chargée de Recherche CNRS, Laboratoire de Recherche sur les Polymères - UMR 7581 CNRS, Université Paris Val de Marne (Paris XII).
  • 1994-1995 : Research Assistant Professor, Research Institute for Biosciences and Institute for Biomedical Engineering, Science University of Tokyo and Tokyo Women’s Medical College.

• Post-doctoral fellow (1993-1994): Department of Materials Science and Research Institute for Biosciences, Science University of Tokyo.
• PhD (1990-1993) : Laboratoire de Chimie Biologique et Macromoléculaire, Université Pierre et Marie Curie (Paris VI). Bourse MESR.
• Master Degree (1989-1990): Chimie Macromoléculaire (mention bien, 1ère), Université Pierre et Marie Curie (Paris VI).

Collaborations

• Dr. Pascal LOYER, Inserm U991, Hôpital Pontchaillou, Université de Rennes 1.
• Dr. Franck CAMEREL, ISCR, Equipe MaCSE, Université de Rennes 1.
• Dr. Olivier COULEMBIER, Center of Innovation and Research in Materials and Polymers (CIRMAP), Laboratory of Polymeric and Composite Materials (LPCM), University of Mons (Belgique).

Scientific Production

Selected scientific production:
• Z.W. Huang, V. Laurent, G. Chetouani, J.Y. Ljubimova, E. Holler, T. Benvegnu, P. Loyer, S. Cammas-Marion, Int. J. Pharm., 2012, 423, 84-92.
• P. Loyer, W. Bedhouche, Z.W. Huang, S. Cammas-Marion, Int. J. Pharm., 2013, 454, 727-737.
• S. Cammas-Marion, P. Loyer, J. Drug Target., 2014, 22(7), 556-575.
• N. Lepareur, L. Leal E. Costa, M. Bocqué, C. Blondelle, C. Ruello, M. Desjulets, N. Noiret, S. Cammas-Marion, Frontiers in Medicine, Section Nuclear Medicine, 2015, 2. doi: 10.3389/fmed.2015.00063.
• E. Vene, K. Jarnouen, Z.W. Huang, B. Wahib, T. Montier, S. Cammas-Marion, P. Loyer. Pharm. Nanotechno., 2016, 4, 24-37.

Invited talks at Conferences: 6
Communications at Conferences: 43
Seminars in Laboratories: 17
Publications: 52
Book Chapter: 3
Democratization of science: Regular intervention in schools and in science festivals.

Publications referenced in HAL