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CNRS Engineer (Ingénieur d’Etude CNRS)

Institut des Sciences Chimiques de Rennes UMR 6226
Université de Rennes 1/ENSCR
Campus de Beaulieu / Villiejean
35042/43 Rennes, France
Building 10A, Office 163
Phone: +33 (0)


Research themes and activities

• Syntheses and physico-chemical characterization in molecular chemistry with therapeutic aims
• Molecular modelling and calculations for molecular properties and biocatalysis
• Participation in equipment management and collective tasks
• Health and safety prevention assistant

Key words / Scientific skills

• Bioorganic chemistry
• Apoptosis inducers
• Protein-ligand interactions

Education and professional experience

• Design and Technical Engineer and research participation, CNRS UMR 6226 ‘Institut des Sciences Chimiques de Rennes’, 2006
• Chemist engineer / Master of Science in Chemical Engineering ENSC-Rennes (2005). Research and Development in CCPA and Bio Armor Development, Rennes.
• Design and Technical Engineer CNRS UMR 7613 ’Synthèse, Structure et Fonctions des Molécules Bioactives’, Peptides and receptors group (2000 - 2005).
• Molecular Modelling and therapeutic chemistry specialization, EA 1795, ENSCR, Pr A. Darchen, in collaboration with the Brittany District and Goëmar Inc (1999 - 2000).
• Teaching at secondary school, Chartres: Physics, Chemistry and Mathematics teacher (1998 - 1999).
• Postgraduate degree ’Organic Chemistry’, University Paris Sud-Orsay and CNRS UPR 2301, Institut de Chimie des Substances Naturelles, Biocatalysis and regulation group, Gif-sur-Yvette (1997).
• Master of Sciences with organic chemistry distinction, University of Orléans (1996) CNRS UMR 5539 Dynamique moléculaire des interactions membranaires, University Montpellier II (1996).

Others activities

• Management participation in case of research project or training course for students
• Rescuer, first-aid worker, 2012 -
• Scientific animation:

  • Chemistry support and administrator of popular education association Les Petits Débrouillards, Nantes, 2007 - 2013 ;
  • ’International Year of Chemistry’: Participation to scientific events (animation by chemistry experiment for schoolchild, teenagers…), visits chemistry labs…during (UNESCO) (teenagers, and all public), Rennes, 2011 ;
  • ’Chimie et Société’, symposium : Logistic support and animation experiments for schoolchild, and all public, Guichen, 2010.

Scientific Production

  1. N. Levoin, D. D. Vo, F. Gautier, S. Barillé-Nion, P. Juin, O. Tasseau and R. Grée (2015). A combination of in-silico and SAR studies to identify binding hot spots of Bcl-xL inhibitors. Bioorg. Med. Chem., 23, 1747-1757
  2. A. Nasr El Dine, O. Tasseau, D. Grée, T. Roisnel, A. Khalaf, S. El-Abdallah, F. Fares, A.. Hachem, R. Grée (2014) New synthesis of chroman-4-ones wit gem-difluoro side chains in position 2. Synlett, 25, 2451-2454.
  3. A. Nasr El Dine, A. Khalaf, D. Grée, O. Tasseau, F. Fares, N. Jaber, A. Hachem and R. Grée (2013) Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains. Beilstein J. Org. Chem., 9, 1943-1948
  4. C. Neveu, B. Lefranc, O. Tasseau, J.-C. Do Régo, A. Bourmaud, P. Chan, P. Bauchat, O. Le Marec, J. Chuquet, L. Guilhaudis, J. A. Boutin, I. Ségalas-Milazzo, J. Costentin, H. Vaudry, M. Baudy-Floc’h, D. Vaudry, and J. Leprince (2012). Rational design of a low molecular weight, stable, potent and long-lasting GPR103 aza-3-pseudopeptide agonist. J. Med. Chem., 55, 7516-7524.
  5. M. Laurencin, O. Tasseau, M. Baudy-Floc’h (2009). Asymmetric synthesis of suitably protected γ-hydroxy-aza β3-homothreonine building blocks. Tetrahedron Asymmetry, 20, 1103 -1105.

Publications referenced in HAL