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Myriam LE ROCH

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Myriam LE ROCH

UR1 - Chemistry Engineer (IE)

Université de Rennes 1
Faculté des Sciences Pharmaceutiques et Biologiques
Pharmacie : Institut des sciences chimiques de Rennes - UMR 6226
2 - AVE du Pr. Léon Bernard - CS 34317 - 35043 - RENNES CEDEX
Building 05-East, Office 00- 033
Phone: +33 (0)

Technical tasks / Responsabilities

• Organic Synthesis (multi-steps synthesis, heterocyclic synthesis, enantioselective synthesis).
• In charge of infrared spectrometry and IR equipment.
• Structural analysis( NMR 1D, NMR 2D, IR, chiral HPLC).
see Multistep or total synthesis and Catalysis

Teaching activities

• Co-supervision of students (IUT, L3, M1, M2).

Scientific Production

23 publictions.

Gold-catalysed synthesis of enantioenriched furfurylamines from amino acids..
B. Guieu, M. Le Roch, M. David, N. Gouault
Tetrahedron: Asymmetry, 2015, 26, 868-875.

On the formation of a Protic Ionic Liquid in Nature.
L. Chen, G.E. Mullen, M. le roch, C.G. Cassity, N. Gouault, H.Y.Fadamiro, R.E. Barletta, R.A. O’Brien, R.E. Sykora, A.C. Stenson, K.N. West, H.E. Horne, J. M. Hendrich, K.R. Xiang and J.H. Davis Jr., Angew. Chem., Int. Ed., 2014, 53, 1-5

Total synthesis of dendrobate alkaloid (+)-241-D, isosolenopsin and isosolenopsin A: application of a gold-catalysed cyclisation .
N. Gouault, M. Le Roch, G. de Campos Pinto, M. David, Org.Biomol. Chem., 2012, 10, 5541.

Enantiospecific Synthesis of Pyridinones as Versatile Intermediates toward Asymmetric Piperidines.
N. Gouault, M. Le Roch, A. Cheignon, P. Uriac, M. David, Org. Lett., 2011, 13, 4371-4373.

Targeting the Polyamine Transport System with Benzazepine- and Azepine-Polyamine Conjugates.
S. Tomasi, J. Renault, B. Martin, S. Duhieu, V. Cerec, M. le Roch, Ph. Uriac, J.G. Delcros, J.Med. Chem., 2010, 53, 7647-7663.

Publications referenced in HAL