Chimie ORganique & INTerfaces

Supervisory authorities

CNRS UR1 ENSCR INSA




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Joëlle VIDAL

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Joëlle VIDAL

Joëlle VIDAL
UR1 Professor

Institut des Sciences Chimiques de Rennes UMR 6226
Université de Rennes 1
Campus de Beaulieu
35042 Rennes, France

Building #10A, Office #160
Phone: +33 2 23 23 57 33
Email: joelle.vidal

Research themes

• Design, synthesis and enzymatic evaluation of proteasome inhibitors
• Stereoselective synthesis of amino-acids
• Organic synthesis
• Electrophilic amination
• Chemistry of heterocycles

Scientific skills

• Peptide synthesis
• Protease inhibition
• Organic chemistry
• Medicinal chemistry

Education and professional experience

• Professor (2000- ), Université de Rennes 1
• Assistant professor, (1989-2000), Ecole normale supérieure de Lyon
• PhD, Université de Paris Sud

Teaching activities

• Organic chemistry (3rd and 4th year students in chemistry)
• General chemistry (2nd year students in biology)
• Chemistry of amino-acids and peptides for chemistry students (master degree)
• General and organic chemistry for students in teacher education (master degree)

Membership in professional organizations

• Société chimique de France (since 1992)
• American chemical society (since 1997)
• Union des professeurs de physique et chimie (since 1984)

Committee work

• Elected member, “conseil académique, commission de la formation et de la vie universitaire”, Université de Rennes 1 (academic council), (2012-2016)
• Alternate member, “Conseil national des universités, section 32”, (French national council of universities, organic chemistry section), (2012-2016)
• Member, “conseil de laboratoire de l’UMR 6226”, (laboratory council), (2012-2016)
• Elected member, « division de chimie organique, Société chimique de France » (organic chemistry division, French chemical society), (2006-2008)

Scientific Production

Selected scientific production
• Vidal, J.; Damestoy, S.; Guy, L.; Hannachi, J. C.; Aubry, A.; Collet, A., N-Alkyloxycarbonyl-3-aryloxaziridines: their preparation, structure, and utilization as electrophilic amination reagents. Chem. Eur. J. 1997, 3 (10), 1691-1709.
• Guy, L.; Vidal, J.; Collet, A.; Amour, A.; Reboud-Ravaux, M., Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors. J. Med. Chem. 1998, 41 (24), 4833-4843.
• Hannachi, J. C.; Vidal, J.; Mulatier, J. C.; Collet, A., Electrophilic amination of amino acids with N-Boc-oxaziridines: Efficient preparation of N-orthogonally diprotected hydrazino acids and piperazic acid derivatives. J. Org. Chem. 2004, 69 (7), 2367-2373.
• Genin, E.; Reboud-Ravaux, M.; Vidal, J., Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry. Curr. Top. Med. Chem. 2010, 10 (3), 232-256.
• Desvergne, A.; Genin, E.; Maréchal, X.; Gallastegui, N.; Dufau, L.; Richy, N.; Groll, M.; Vidal, J.; Reboud-Ravaux, M., Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome. J. Med. Chem. 2013, 56 (8), 3367-3378.

Book Chapter

Vidal, J., Synthesis and chemistry of α-hydrazino acids. In Amino Acids, Peptides and Proteins in Organic Chemistry, Hughes, A., Ed. Wiley-VCH: 2009; Vol. 2, pp 35-92.

Patent 6

Publications Referenced in HAL