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Jean-Pierre BAZUREAU

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Jean-Pierre BAZUREAU

UR1 Full Professor

Professeur 1ere Classe
Institut des Sciences Chimiques de Rennes UMR 6226
Université de Rennes 1
Campus de Beaulieu
35042 Rennes, France
Building 10A, Desk 207
Phone: +33 (0) 2.23.23.66.03
Click here to send an e-mail

Research Themes

• Organic synthesis under microwave irradiation for development of marine alkaloid analogues as specific inhibitors of protein kinases (cancer, central nervous system CNS, tropical diseases)
• Synthetic development of modulators and imaging fluorescent probes for ion channels in cancer,
• Ionic liquid chemistry associated to microwave in “Ionic Liquid Phase Organic Synthesis methodology” and Brönsted Ionic Liquid approach for catalysis
• Microwave irradiation in heterochemistry for lab scale-up process

Key Words / Scientiofic Skills

• leucettine, Alzheimer’s disease, Down syndrome
• marine alkaloid analogues
• Ion channel, cancer, fluorescent probes, modulators of protein
• ionic liquid, molecular design
• organic synthesis assisted by microwave irradiation & multi-step organic synthesis

Education and professional experience

• • 1984-1987: PhD in Organic Synthesis, University of Rennes 1, France
• 1987-1988: R&D Process engineer in industry
• 1988-1991: Chief responsible of a “Life Sciences Lab” in international engineering & manufacturing company
• 1991: University of Rennes 1, France, URA CNRS 704, Assistant professor in Jack Hamelin’s group
• 1997: University of Rennes 1, UMR CNRS 6510, France: D. Sc. in Chemistry (Habilitation à diriger des Recherches)
• 2003-2006: University of Rennes 1, France, UMR CNRS 6510, Professor
• 2006-present: University of Rennes1, France, Institut des Sciences Chimiques de Rennes, ISCR UMR CNRS 6226, Professor
• 2015: Founder and Chief responsible of S2 Wave “Santé Synthèse Micro-Onde” platform in ScanMAT SFS of University of Rennes1, France.

Teaching activities

• “Building-block strategies & hetero-chemistry” in Master Sc. of Molecular Chemistry
• “Advanced course on techniques for separation (hplc & gpc)” in Master Sc. of Analytical Chemistry
• “Crop chemistry” in Master Sc. of Plant Biology
• “Ionic liquid Chemistry & Microwave Synthesis: from lab to bulk” in International Master Sc. of Catalysis & Molecular Chemistry
• Master Sc. of Analytical Chemistry: administrative responsible 2007-2013

Membership in professional organizations

• Member in“Ion Channels Network”, Cancéropôle Grand Ouest CGO since 2012
• Member in “Making the best use of products from the sea in cancerology”, Cancéropôle Grand Ouest CGO since 2003
• Member in Therapeutic Chemistry Society (SCT) since 2013
• Member (nominated) in “Athens Institute for Education and Research ATINER”: chemistry & pharmaceutical units since (2015-2016).
• Corresponding referent of ISCR for “French National Chemical Library of CNRS” since 2017

Committee work

• ISCR Board regent (elected): 2012-2016
• Scientific expert for High Council for French Evaluation of the Research and Higher Education (HCERES): 2008 & 2014-2015.
• Editorial Board Member of Pharmaceuticals, MDPI AG since 2015.

Awards

• Top-50 Tetrahedron Most Cited Paper 2003-2006 Award for Tetrahedron 2003, 59, 6121-6130. 232nd ACS Full National Meeting “Cycle of Excellence”, San Francisco (USA), September 10, 2006.
• Top-50 Tetrahedron Most Cited Paper 2004-2007 Award for Tetrahedron 2004, 60, 3745-3753.
• ACS “Most-Accessed Articles” Award: October-December 2006 for J. Comb. Chem. 2006, 8, 829-833.

Collaborations

• Prof. Yves-Alain Bekro & Prof. Janat Mamyrbékova: University of Nangui Abrogoua UNA, Abidjan, Côte d’Ivoire with “Laboratoire de Chimie-Bioorganique & des Subtances Naturelles LCBOSSN”.
• Dr Wacothon Karim Coulibaly: University of Péléforo Gon Coulibaly, Korhogo, Côte d’Ivoire.
• Prof. Houcine Ammar, Prof. Souhir Abid & Dr Medhi Fakhfakh: University of Sfax, Sfax, Tunisie with “Laboratoire de Chimie Appliquée: Hétérocycles Corps Gras Polymères LR 01ES22”.
• Dr Laurent Meijer, CEO & Scientific Director, ManRos Therapeutics, Roscoff.
• Dr Olivier Mignen, Dr Christophe Brigaudeau: Inserm U1078 Université de Bretagne Occidentale (UBO), Brest, with “Laboratoire Canalopathies & Signalisation Calcique”
• Dr Sandrine Ruchaud, Dr Stéphane Bach: KISSf platform, Station Biologique CNRS, Roscoff.

Scientific Production

Selected scientific productions
1. CLK/DYRK kinases inhibitor Leucettine L41 induces mTOR-dependent autophagy. Implication for Alzheimers’ disease.
X. Fant, E. Durieu, G. Chicanne, B. Payrastre, D. Sbrissa, A. Shisheva, E. Limanton, F. Carreaux, J-P. Bazureau, L. Meijer. Mol. Pharm. 2014, 85, 441-450. doi: 10.1124/mol.113.090837
2. Selectivity, co-crystal structures and neuroprotective properties of Leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid Leucettamine B.
T. Tahtouh, O. Federov, M. Soundararajan, G. Burgy, E. Durieu, O. Lozach, C. Cochet, R. S. Schmid, D. C. Lo, F. Delhommel, A. E. Oberholzer, L. H. Pearl, F. Carreaux, J-P. Bazureau, S. Knapp, L. Meijer. J. Med. Chem. 2012, 55, 9312-9330. doi: 10.1021/jm301034u
3. An efficient approach to dispacamide A an its derivatives.
S. Guiheneuf, L. Paquin, F. Carreaux, E. Durieu, L. Meijer, J-P. Bazureau. Org. Biomol. Chem. 2012, 10, 978-987. doi: 10.1039/C1OB06161E
4. Leucettines, a class of potent CLK and DYRK kinases inhibitors derived from the marine sponge leucettamine B. Modulation of alternative RNA splicing.
M. Debdab, F. Carreaux, S. Renault, M. Soundararajan, O. Federov, O. Lozach, L. Babault, B. Baratte, Y. Ogawa, M. Hagiwara, A. Einsenreich, U. Rauch, S. Knapp, L. Meijer, J-P. Bazureau. J. Med. Chem. 2011, 54, 4172-4186. doi: 10.1021/jm200274d
5. Efficient combination of task-specific ionic liquid and microwave dielectric heating applied to a one-pot three component synthesis of a small library of 4-thiazolidinones.
J. Fraga-Dubreuil, J-P. Bazureau. Tetrahedron 2003, 59, 6121-6130. doi: 10.1016/S0040-4020(03)00954-2

Invited talks at Conferences: 26
Communications, key notes at Conferences: 52
Conferences in industry: 4
Publications: 108
Book Chapters: 6
Patents: 4
Democratization of science: Regular intervention in schools and in science festivals. Amphi Lycéens 2014 & 2015


Publications referenced in HAL