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Gérard SIMONNEAUX

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Gérard SIMONNEAUX

CNRS Director of Research

Directeur de Recherche

Institut des Sciences Chimiques de Rennes UMR 6226
Université de Rennes 1
Campus de Beaulieu
35042 Rennes, France

Building 10C, Desk 143
Phone: +33 (0) 2.23.23.62.85
Click here to send an e-mail

Research themes

• Bioinorganic chemistry
• Asymmetric Catalysis
• Bioconjugation
• Artificial Proteins

Keywords

• Porphyrin
• Paramagnetic NMR
• Catalysis
• Chiral Metalloporphyrins (Fe, Mn, Ru)

Education and Professional experience

• Director of research CNRS (2000-)
• Post-doctoral fellow (1980, USC Los Angeles)
• PhD in Chemistry (1979)

Collaborations

• Professor Mikio Nakamura
• Professor Ann Walker
• Dr Joelle Rault-Berthelot
• Dr Gilles Salbert

Scientific Production

3 areas of research are at present developed :

  • The bioconjugation of proteins with diazoporphyrins (fluorescent or phosphorescent)
  • The asymmetric catalysis with cupric complexes optically active
  • The design, the synthesis and the characterization of artificial metalloenzymes

Selected scientific production :
• Enantioselective Manganese-Porphyrin-Catalyzed Epoxidation and C-H hydroxylation with Hydrogen Peroxide in Water/Methanol Solutions. H. Srour, P. Le Maux and G. Simonneaux, Inorg. Chem. 2012, 51, 5850-5856.
• Biological properties and interaction with recombinat HDAC7 of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are affected by short alkylgroup substitution of the phenyl ring. F. Oger, A. Lecorgne, E. Sala, S. Chevance, D. Desravines, P. Barath, D. Hart, A. Bondon, D. Carettoni, G. Simonneaux, G. Salbert. J. Med. Chem. 2010, 53, 1937-1950
• Isolation, X-ray crystal structure, and reactivity of a new C-H carbene complex of (5,10,15,20,-Tetraphenylporphyrinato)ruthenium(II), P. Le Maux, T. Roisnel, I. Nicolas, P. and G. Simonneaux, Organometallics. 2008, 27, 3037-3042
• Mechanism of Electron Transfer in Heme Proteins and Models: the NMR Approach. Gérard Simonneaux and Arnaud Bondon. Chem. Rev., 2005, 105, 2627-2646
• Structural, Magnetic and Dynamic Characterization of the (dxzdyz)4 (dxy)1 Ground State Low-Spin Iron(III) Tetraphenylporphyrinate Complex [(p-TTP)Fe(2,6-XylylNC)2]CF3SO3. G. Simonneaux, V. Schünemann, C. Morice, L. Carel, L. Toupet, H. Winkler, A. X. Trautwein, F. A. Walker J. Am. Chem. Soc. 2000, 122, 4366-4377.

Invited talks at Conferences: 29
Publications: 180
Book Chapter: 10

Publications referenced in HAL