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Françoise LOHEZIC-LE DEVEHAT

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Françoise LOHEZIC-LE DEVEHAT

UR1 - Assistant Professor

Université de Rennes 1
Faculté des Sciences Pharmaceutiques et Biologiques
Pharmacie : Institut des sciences chimiques de Rennes - UMR 6226
2 - Av du Pr. Léon Bernard - CS 34317 - 35043 - RENNES CEDEX
Building 05-East, Office 04-424
Phone: +33 (0) 2.23.23.48.16
Email: francoise.le-devehat@univ-rennes1.fr/ensc-rennes.fr

Research themes / Technical skills

• Involved in natural substances phytochemistry (Extraction, Isolation, and Identification of secondary metabolites from various Natural Sources (plants, lichens).
• Valorisation of the isolated compound for their bioactivity (antiviral, cytotoxic, antioxidant,… biological targets) in order to have applications for pharmaceuticals and/or cosmetics.

Key words / Scientific skills

• Phytochemistry.
• Lichens.
• Chemical ecology.
• Biological activities.

Education and professional experience

• Lecturer and Assistant Professor (2004- , PNSCM team)
• PhD - Pharmacognosy - Rennes (1998-2002) (Soutenue le 8 novembre 2002 à Rennes), Faculty of Pharmacy, Rennes, Lab. Pharmacognosy and Mycology)
• Dr in Pharmacy, University Rennes1 and Dr Pharmacy specialist (2001)
• Internat – Resident Pharmacy specialist (1996-2000)
• Master 2 – Cellular Biology and Sciences for Health (University of Rennes I) (1998).

Teaching activities

• Pharmacognosy
• Mycology
• Phytotherapy and aromatherapy
• Toxic Plants Pharmacy
• Nutraceutics.

Membership in professional organizations

• AFERP (French Speaking Society for Teaching and Research in Pharmacognosy) http://www.aferp.univ-rennes1.fr/ ),
• STOLON (Teaching & research in Botany-Mycology)
• AFL (French Lichen Society) and IAL (International Association for Lichenology).

Collaborations

• Philippe Legrand / Daniel Catheline, Laboratoire de Biochimie, Institut National de la Recherche Agronomique, USC 1378, Agrocampus-Ouest, Rennes, France.
• Jacques Le Seyec, INSERM, UMR-1085, Institut de Recherche Santé Environnement & Travail (IRSET) et Fédération de Recherche BioSit, Rennes, France.
• Olivier Delalande, UMR CNRS 6290 IGDR, Equipe SIM, Faculté des Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, France.
• Dr. Birgit WALTENBERGER, Institut für Pharmazie / Pharmakognosie, Universität Innsbruck, Innsbruck, Autriche.
• Holger Thus, Natural History Museum, Cromwell Road, London, SW7 5BD, United Kingdom.
• Pr Charles Vairappan, Director Institute for Tropical Biology and Conservation, University of Malaisia, Sabah
• Maryvonne Charrier, OSUR (Rennes 1), Observatoire des sciences de l’univers de Rennes (Rennes 1).
• Sophie Le Gall et Hélène Rogniaux, Plate-forme Biopolymères Biologie Structurale, Centre de recherche Angers-Nantes Unité BIA, Nantes, France.

Scientific Production

21 international Peer Review publications.
1 international Patent.
2 Book Chapters.
4 national publications.
39 Communications.

T.H. Vu, D. Catheline, D. Delmail, J. Boustie, P. Legrand and F. Lohézic-Le Dévéhat*. Gas chromatography analysis to compare the fatty acid composition of fifteen lichen species, with a focus on Stereocaulon species. The lichenologist, accepted le 8/02/2016.

T. H. Vu, A.-C. Le Lamer, C. Lalli, J. Boustie, M. Samson, J. Le Seyec*, F. Lohézic-Le Dévéhat*. Depsides: lichen metabolites active against hepatitis C virus“., PlosOne, published: March 20, 2015 - DOI: 10.1371 / journal.pone.0120405

T. T. T. Nguyen, M. Chollet-Krugler, F. Lohézic-Le Dévéhat, I. Rouaud, J. Boustie* “Mycosporine-like compounds in Chlorolichens : isolation and photoproptective properties from Dermatocarpon luridum and Dermatocarpon miniatum“, Planta Medica Letters (accepté en dec 2014) Planta Medica Letters 03/2015; 2(01):e1-e5. DOI: 10.1055/s-0034-1396321.

J. Boustie., M.D. Galibert, F. Lohézic – Le Dévéhat, M. Chollet., S. Tomasi., B. Legouin-Gargadennec. 2013. Acide lichesterinique et ses dérivés comme inhibiteurs de la pigmentation. Dépôt INPI N°FR 12.53585 18 04 2012 , PCT Int. Appl. 2013, WO 2013156738 A2 20131024.

F.Lohezic-Le Devehat*, B. Legouin*, C. Couteau, J. Boustie, L. Coiffard, Lichenic extracts and metabolites as UV filters, J Photochem Photobiol B. (2013),120:17-28.

Friardi Ismed, Françoise Lohézic-Le Dévéhat*, Olivier Delalande, Sourisak Sinbandhit, Amri Bakhtiar, and Joël Boustie. Lobarin from the Sumatran lichen, Stereocaulon halei, Fitoterapia (2012), 83 (8),1693-1698.

Lohézic – Le Dévéhat F., Tomasi S., Elix J., Bernard A., Rouaud I., Uriac P., , Boustie J*. Stictic acid derivatives from the lichen Usnea articulata L. and their antioxidant activities, J. Nat. Prod. (2007), 70, 1218-1220

Publications referenced in HAL