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Florence MONGIN

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Florence MONGIN

UR1 Professor

Institut des Sciences Chimiques de Rennes UMR 6226
Université de Rennes 1
Campus de Beaulieu
35042 Rennes, France

Building #10A, Office #018
Phone: +33 2 23 23 69 31
Email: florence.mongin

Research themes

• synergic reagents in deprotonative metallation
• chemoselective functionalization of aromatic heterocycles
• substituent effects and C-H functionalization
• stereoselective syntheses of ferrocene derivatives
see Bimetallic synergy

Scientific skills

• bimetallic bases
• aromatic heterocycles
• C-H functionalization
• substituent effects
• ferrocenes

Education and professional experience

• Professor (2005-), University of Rennes 1, Institut des Sciences Chimiques de Rennes, UMR 6226 (France)
• Junior member of the Institut Universitaire de France (2009-2014)
• D. Sc. in Chemistry (Habilitation à Diriger des Recherches, 2003), University of Rouen (France)
• Assistant-professor (1997-2004), University of Rouen, Institut de Recherche en Chimie Organique Fine, UMR CNRS 6014 (France)
• Post-doctoral fellow (1995-1997), Institute of organic Chemistry, University of Lausanne (Switzerland)
• PhD (1991-1994), University of Rouen (France)


• Masanobu Uchiyama and Ryo Takita, RIKEN and University, Tokyo (Japan)
• Palakodety Radha Krishna, Hyderabad (India)
• Andrew Wheatley, Cambridge (UK)
• Luis Domingo, Valencia (Spain)
• Yury Halauko, Minsk (Byelorussia)
• Göran Hilmersson, Göteborg (Sweden)
• Lennart Bunch, Copenhagen (Denmark)
• Michel Frédérich, Liège (Belgium)

Scientific Production

Florence Mongin obtained her PhD in chemistry in 1994 from the University of Rouen under the supervision of Prof. Guy Quéguiner. After a two years stay at the Institute of Organic Chemistry of Lausanne as a post-doctoral fellow with Prof. Manfred Schlosser, she returned to the University of Rouen as an Assistant Professor in 1997 (habilitation in 2003). Besides research activities concerning the functionalization of heteroaromatic compounds using lithium and magnesium reagents, and the synthesis of biologically active compounds, she got involved in catalysis studies, notably for the activation of C-F bonds, and the transition metal C-C bond formation using Grignard reagents in the presence of reactive functional groups. She has thus expertise in the functionalization of aromatic and heterocyclic compounds, in the synthesis and use of metal bases, and in metal-catalyzed coupling reactions.
She took up her present position in 2005 as Professor at the University of Rennes, and was appointed Junior member of the Institut Universitaire de France in 2009. Her present scientific interests include the functionalization of aromatic and heteroaromatic compounds, and in particular the use of synergic bimetallic bases for this purpose. Recourse to lithium-metal (magnesium, zinc, cadmium, copper, cobalt, and iron) combinations notably allowed deproto-metallation reactions of various substrates and their subsequent trapping. Extensions to the diastereoselective functionalization of sugar-based ferrocenes using bimetallic bases, and to the enantioselective deprotonation of simple ferrocenes or biaryls using chiral bimetallics are currently under investigation.

Selected Publications
Long-range effect of bromine in the deprotonative metalation of aromatic compounds.
Mongin, F.
Chimia 2016, 70, 48 (special issue ‘The French Connection’).
New avenues in the directed deprotometallation of aromatics: recent advances in directed cupration
Harford, P. J.; Peel, A. J.; Chevallier, F.; Takita, R.; Mongin, F.; Uchiyama, M.; Wheatley, A. E. H.
Dalton Trans., Polar Organometallics themed issue, 2014, 43, 14181.
Computed CH acidity of biaryl compounds and their deprotonative metalation using a mixed lithium-zinc TMP base.
Kadiyala, R. R.; Tilly, D.; Nagaradja, E.; Roisnel, T.; Matulis, V. E.; Ivashkevich, O. A.; Halauko, Y. S.; Chevallier, F.; Gros, P. C.; Mongin, F.
Chem. Eur. J. 2013, 19, 7944.
Mixed AggregAte (MAA): a single concept for all dipolar organometallic aggregates. 2. Syntheses and reactivities of homo/heteroMAAs.
Mongin, F. ; Harrison-Marchand, A.
Chem. Rev. 2013, 113, 7563.
Synthesis of both enantiomers of ferrocene[1,2-c]1H-quinolin-2-one by diastereoselective deproto-zincation of sugar-derived ferrocene esters.
Sreeshailam, A.; Dayaker, G.; Venkata Ramana, D.; Chevallier, F.; Roisnel, T.; Komagawa, S.; Takita, R.; Uchiyama, M.; Radha Krishna, P.; Mongin, F.
RSC Adv. 2012, 2, 7030.

Publications: 120

Book Chapters:

5. Deprotonative Metalation Using Alkali Metal-Non Alkali Metal Combinations.
Chevallier, F. Mongin, F.; Takita, R.; Uchiyama, M. dans Arene Chemistry: Reaction Mechanisms and Methods for Aromatic Compounds, Wiley-VCH, Ed.: Mortier, J. 2016, Chap. 27, 777-812.
4. Lithiations and magnesiations on quinoline and isoquinoline.
Chevallier, F.; Mongin, F. dans Metalation of Azines and Diazines, Book series “Topics in Heterocyclic Chemistry”, Springer, Eds.: Schnürch, M.; Mihovilovic, M. D. 2013, 31, 93-130.
3. Chemistry and Biological Activity of Isoquinoline and Related Compounds.
Bazureau, J. P.; Mongin, F.; Hamelin, J. dans Selected methods for synthesis and modification of heterocycles, Vol. 7:, ICSPF Press, Ed.: V. G. Kartsev, 2008.
2. Quinoline Functionalization by Deprotonative Metalation.
L’Helgoual’ch, J.-M.; Chevallier, F.; Mongin, F. Targets Heterocycl. Syst., 2007, 11, 155-180.
1. Microwaves in heterocyclic chemistry.
Hamelin, J.; Bazureau, J. P.; Mongin, F.; Texier-Boullet, F. dans Microwaves in Organic Synthesis, Wiley-VCH, Ed.: A. Loupy, 2006, Chap. 10, 456-523.

Publications Referenced in HAL