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Claudia LALLI

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Claudia LALLI

CNRS Researcher (CR)

Université de Rennes 1
Faculté des Sciences Pharmaceutiques et Biologiques
Pharmacie : Institut des sciences chimiques de Rennes - UMR 6226
2 - Av du Pr. Léon Bernard - CS 34317 - 35043 - RENNES CEDEX
Building 05-East, Office 00- 030
Phone: +33 (0) 2.23.23.31.06
Email: claudia.lalli

http://blogperso.univ-rennes1.fr/claudia.lalli/

Research themes / Technical skills

• Catalytic enantioselective Prins cyclization
• Catalytic aza-Prins cyclization
• New (chiral) ligands for the Zn-catalyzed hydrosylilation and ZnEt2 addition to carbonyls
see Catalysis

Key words / Scientific skills

• Catalytic enantioselective transformations.
• Chiral organocatalysts and organometallic catalysts.
• Small libraries of molecular scaffolds for drug discovery.
• Medicinal chemistry.

Education and professional experience

• Actual position (2012- , CNRS Researcher, University of Rennes 1, UMR CNRS 6226)
• post-doctoral fellow (2009-2012, ICSN Gif sur Yvette FRANCE)
• PhD (2006-2009, University of Florence ITALY)
• Master Degree (2005, University of Florence ITALY)

Teaching activities

• Practical Works in Organic Chemistry to Chemistry Department of the IUT in Rennes.

Membership in professional organizations

• President of the Club of Young Researcher, Bretagne-Pays-de-Loire of the French Chemical Society 2015-2019.

Committee work

• Member of the Organizing Committee of the 6th Symposium Français de Synthèse Totale in Rennes the 31st May and 1st July 2016.

Awards

• Allocation d’Installation Scientifique (AIS) « jeune chercheur » de Rennes Métropole 2013.

Collaborations

• Dr. Paolo Larini, assistant Professor at the University Claude Bernard Lyon 1 for DFT calculations.
• Dr. B. V. Subba Reddy, IICT Indian Institute of Chemical Technology in Hyderabad India, (Indo-French Joint Laboratory for Sustainable Chemistry at Interfaces AIL IICT/CSIR - CNRS/UR1) on the enantioselective tandem reactions involving a Prins process.
• Dr. B. Le Grel and Dr. P. Le Grel, UMR 6226, on the synthesis of picolinohydrazides as new class of ligands for the Zn catalyzed hydrosylilation of carbonyls.
• Pr. François-Xavier Felpin, University of Nantes UMR 6230 CEISAM, on the design and synthesis of new chiral catalysts for the development of the enantioselective Heck-type reactions through an unprecedented chiral counterion strategy: from the batch chemistry to the flow approach.

Scientific Production

Selected publications:

Synergistic effect of the TiCl4/p-TsOH promoter system on the aza-Prins cyclization V. Durel, C. Lalli; T. Roisnel, P. van de Weghe, J. Org. Chem. 2016, 81, 849-859.

Catalytic, Highly Enantioselective, Direct Amination of Enecarbamates A. Dumoulin, C. Lalli, G. Masson, Chem. Commun. 2015, 51, 5383-5386.

Chiral Calcium−BINOL Phosphate Catalyzed Diastereo− and Enantioselective Synthesis of syn−1,2−Disubstituted 1,2−Diamines: Scope and Mechanistic Studies C. Lalli, A. Dumoulin, C. Lebée, F. Drouet, V. Guérineau, D. Touboul, V. Gandon, J. Zhu, G. Masson, Chem. Eur. J. 2015, 21, 1704-1712.

Enantioselective Prins Cyclization: BINOL-Derived Phosphoric Acid and CuCl Synergistic Catalysis C. Lalli, P. van de Weghe, Chem. Commun. 2014, 50, 7495-7498.
Highly Enantioselective Electrophilic α-Bromination of Enecarbamates: Chiral Phosphoric Acid and Calcium Phosphate Salt Catalysts A. Alix, C. Lalli, P. Ratailleau, G. Masson, J. Am. Chem. Soc. 2012, 134, 10389−10392. Selected by SINFACTS 2012, 9, 1023.

Patent:
Heterocyclic Compounds Containing the Morpholine Nucleus their Preparation and Use. Guarna, A.; Trabocchi, A.; Menchi, G.; Lalli, C.; Sladojevich, F.; Cini, N. WO2008/129004, October 30th 2008.

Invited talks at Conferences:
Asymmetric Organocatalysis and Application in Organic Synthesis: BINOL-Derived Phosphoric Acid and CuCl Synergistic Catalysis for the First Enantioselective Prins Cyclization. Lalli C. Indo-French Conference “New Trends in Chemistry and Chemical Biology with a Special Focus on CNS Disorders” Organized by CSIR-IICT and supported by CEFIPRA Pondicherry – India - 9-12 November 2014.

Publications before 2010, non-referenced in HAL

Publications referenced in HAL