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Laurent Legentil

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Laurent Legentil

CNRS - Researcher (CR)

Institut des Sciences Chimiques de Rennes UMR 6226
ENSCR
11 allée de Beaulieu
CS 503837
35708 Rennes cedex 7, France

Building B, Office 101 bis
Phone: +33 (0) 2.23.23.81.40
Email: laurent.legentil@ensc-rennes.fr

Research themes

The main aim of our research group is to combine organic chemistry and biochemistry in order to develop innovative synthetic pathways. The targeted structures are glycoconjugates and glycodendrimers that possess immunostimulant and/or antiparasitic properties. Based on our targets, we wish to discover unexplored therapeutic means against some re-emerging diseases (tuberculosis, leishmaniasis, ...) or cancer. These activities can be illustrated through three main projects:
• Development of new antiparasitic agents derived from galactofuranose
• Conception of neo-β-(1,3)-glucans as new immunomodulators
• Modification of the natural activity of glycosidases thanks to molecular biology.

Key words / Scientific skills

• Carbohydrate chemistry and nucleotide synthesis: glycosylation, protecting groups, glycopeptides and glycodendrimers synthesis.
• Green chemistry: biocatalysis , atom economy, new media.
• Heterocyclic chemistry : multi-step synthesis, total synthesis of natural products and analogs, micro-wave assisted reactions, enantioselective catalysis.

Education and professional experience

• Researcher at CNRS, UMR 6226, Team Chimie Organique et Supramoléculaire, Rennes (2008-).
• Researcher at IRL (Industrial Research Ltd), Lower Hutt, New-Zealand (2006-2007).
• Research assistant, School of Chemical Sciences and Pharmacy, University of East-Anglia, Norwich, Great-Britain (2004-2007).
• PhD in chemistry of biomolecules, UMR CNRS 5068, Toulouse (2001-2004).
• Master degree in organic and macromolecular chemistry, Specialty: Drug Design; Université de Lille I, Lille (2000-2001).
• French Engineer Diploma, Specialty Organic chemistry; HEI (Hautes Etudes d’Ingénieur), Lille (1996-2001)

Membership in professional organizations

• Member of the French Group in Glycosciences
• Member of the French Canceropole
• Member of the scientific council of the ENSCR (Elected in 2010 and 2014)

Awards

• Laureate of the Bernard Fournet-André Verbert 2013 award

Collaborations

• Member of the LIA Rennes-Hyderabad

Scientific Production

Selected scientific production:
1. Dureau, R.; Gicquel, M.; Artur, I.; Guegan, J.-P.; Carboni, B.; Ferrieres, V.; Berree, F.; Legentil, L. Org. Biomol. Chem. 2015, 13, 4940-4952.
2. Suleman, M.; Gangneux, J.-P.; Legentil, L.; Belaz, S.; Cabezas, Y.; Manuel, C.; Dureau, R.; Sergent, O.; Burel, A.; Daligault, F.; Ferrieres, V.; Robert-Gangneux, F. Antimicrob. Agents Chemother. 2014, 58, 2156-2166.
3. Sylla, B.; Legentil, L.; Saraswat-Ohri, S.; Vashishta, A.; Daniellou, R.; Wang, H.-W.; Vetvicka, V.; Ferrieres, V. J. Med. Chem. 2014, 57, 8280-8292.
4. Pennec, A.; Legentil, L.; Herrera-Estrella, L.; Ferrieres, V.; Chauvin, A.-L.; Nugier-Chauvin, C. Green Chem. 2014, 16, 3803-3809.
5. Dureau, R.; Legentil, L.; Daniellou, R.; Ferrieres, V. J. Org. Chem. 2012, 77, 1301-1307.

Democratization of science:
• Member of the organizing committee of the « Fête de la science » within the UMR 6226 since 2009.
• Participation to the « Festival des Sciences de Rennes Métropole » (each year since 2010).
• Part of the committee that organize the visits of the research laboratories at ENSCR.

Publications referenced in HAL